DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and STK17B

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_004217.1	Gene:	STK17B / 9262	HGNCID:	11396	Length:	372	Species:	Homo sapiens

Alignment Length:	270	Identity:	64/270 - (23%)
Similarity:	124/270 - (45%)	Gaps:	29/270 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 YIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQTQSND-RGDTYMEAEVLRQLQSHPNIIEL 211
            ||.|.:.:......::.:..:::...:...|.:.|:.:..| |.:...|..||...:|.|.:|.|
Human    32 YILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 96

  Fly   212 MYTVEDERYMYTVLEHLD-------CNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHR 269
            ....|:...:..:||:..       |    :.:...::||.|...:::..:..:.::||..::|.
Human    97 HEVYENTSEIILILEYAAGGEIFSLC----LPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHL 157

  Fly   270 DIKPENLLVCSSSGKWNFKMVKVANFDLATYYRGSKLYVRC------GTPCYMAPEMIAMSGYDY 328
            |:||:|:|:   |..:....:|:.:|.::     .|:...|      |||.|:|||::.......
Human   158 DLKPQNILL---SSIYPLGDIKIVDFGMS-----RKIGHACELREIMGTPEYLAPEILNYDPITT 214

  Fly   329 QVDSWSLGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSD 393
            ..|.|::|:..:.:|....||..  ::::|.|..|......|.::..|.:|..||..|..|||.:
Human   215 ATDMWNIGIIAYMLLTHTSPFVG--EDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKN 277

  Fly   394 PSYRVPIAEL 403
            |..| |.||:
Human   278 PEKR-PTAEI 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	61/254 (24%)
		PKc_like	164..403	CDD:304357	60/252 (24%)
STK17B	NP_004217.1	STKc_DRAK2	24..293	CDD:271100	64/270 (24%)
STK17B	NP_004217.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900