Protein Alignment CG10177 and DCLK1

DIOPT Version :9

• Sequence 1: NP_651150.1
• Gene: CG10177 / 42772
• FlyBaseID: FBgn0039083
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001317000.1
• Gene: DCLK1 / 9201
• HGNCID: 2700
• Length: 740
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 142/642 - (22%)
• Similarity: 212/642 - (33%)
• Gaps: 273/642 - (42%)

  Fly     4 QSTSLGSRRVG--PPLH------------------KKALRVCFLRNGDRHFKGVNLVISRAHFKD 48
            |..|.|||..|  .|.|                  |||.:|.|.|||||:|||:...||...|:.
Human    19 QRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRS 83

  Fly    49 FPALLQGVTESLKRHVLLRSAIAHFRRTDG-SHLTSLSCFRETDIVIC----------CCKN--- 99
            |.|||..:|.:|..:|.|...:......|| ..::||....|.:..:|          ..||
Human    84 FEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNP 148

  Fly   100 ----------------------------------------------------------------- 99
                                                                             
Human   149 NWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSF 213

  Fly   100 --------------------------EEIICV----------------KYSINKDFQRMVDSCK- 121
                                      ::::|:                |:....||......|:
Human   214 EQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRV 278

  Fly   122 ----------------------------------------------------------------- 121
                                                                             
Human   279 VKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRK 343

  Fly   122 -RWGQHHLDSGTL------ESMKSHDLP------EAIQLYIETIEPVEHNTRTLIYR-GQT---- 168
             |..||...|.:|      .||..:|.|      |..|:      |.   |.|..|: |:|
Human   344 QRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQI------PA---TITERYKVGRTIGDG 399

  Fly   169 ----------RANRTKCTVKMVNKQTQSNDRGDTYM---EAEVLRQLQSHPNIIELMYTVEDERY 220
                      |:...:..:|::.|   |..||..:|   |..:||::: ||||:.|:..::....
Human   400 NFAVVKECVERSTAREYALKIIKK---SKCRGKEHMIQNEVSILRRVK-HPNIVLLIEEMDVPTE 460

  Fly   221 MYTVLEHLDCNMQKVIQKRGIL----------SEADARSVMRCTVSALAHMHQLQVIHRDIKPEN 275
            :|.|:|         :.|.|.|          :|.||..::....||:.::|.|.::||||||||
Human   461 LYLVME---------LVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPEN 516

  Fly   276 LLVCSSSGKWNFKMVKVANFDLATYYRGSKLYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTLF 340
            |||.....  ..|.:|:.:|.|||...| .||..||||.|:|||:||.:||..:||.|:.||..:
Human   517 LLVYEHQD--GSKSLKLGDFGLATIVDG-PLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITY 578

  Fly   341 YMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYR 397
            .:|||..||..:..:.:.::..|:.|...:|......:|..|.:||..:|:.|...|
Human   579 ILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQR 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711	35/228 (15%)
		S_TKc	164..409	CDD:214567	83/262 (32%)
		PKc_like	164..403	CDD:304357	83/262 (32%)
DCLK1	NP_001317000.1	DCX1_DCLK1	55..143	CDD:340660	29/87 (33%)
		DCX2	182..265	CDD:340589	2/82 (2%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..378		9/90 (10%)
		STKc_DCKL1	383..650	CDD:271085	86/272 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	697..740

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770