DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and PSKH2

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_016869418.1	Gene:	PSKH2 / 85481	HGNCID:	18997	Length:	504	Species:	Homo sapiens

Alignment Length:	243	Identity:	69/243 - (28%)
Similarity:	119/243 - (48%)	Gaps:	17/243 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IYRGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAEVLRQLQSHPNIIELMYTVEDERYMYTVLEH 227
            :.|.:.:..:....:|::..: :...|.....|..|||:: ||..|::||...|.|..:|.|:|.
Human   196 VVRVEQKTTKKPFAIKVMETR-EREGREACVSELSVLRRV-SHRYIVQLMEIFETEDQVYMVMEL 258

  Fly   228 LDCN--MQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMV 290
            ....  ..::| .:|..:|.||..:::.....:.::|.||:.||::||||||......:   ..:
Human   259 ATGGELFDRLI-AQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEE---SKI 319

  Fly   291 KVANFDLATYYRGSK-----LYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTLFYMLCGKMPFA 350
            .:.:|.||  |.|.|     :...||||.|:|||::....|...||.|:|||..:.:|.|.:||.
Human   320 LITDFGLA--YSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFD 382

  Fly   351 SACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRV 398
            .  ::...:|..|:.|...|..:....:|..|...||.||:.:..:|:
Human   383 D--ESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRM 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	69/242 (29%)
		PKc_like	164..403	CDD:304357	69/242 (29%)
PSKH2	XP_016869418.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900