DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and VHS1

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_010533.1	Gene:	VHS1 / 851834	SGDID:	S000002655	Length:	461	Species:	Saccharomyces cerevisiae

Alignment Length:	237	Identity:	56/237 - (23%)
Similarity:	97/237 - (40%)	Gaps:	38/237 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 YMEAEVLRQLQSHPNIIELMYTVEDERYMYTVLEHLDCNM-QKVIQKR-----GILSEADARSVM 251
            |.|..:..::..|.||:.:...::.....:.|:::...:: ..::..|     |:|    .:.|.
Yeast   106 YKEISLHLRVHHHKNIVTIHEVLQSAVCTFIVMDYYPTDLFTSIVDNRHFVTNGLL----VKKVF 166

  Fly   252 RCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMVKVANFDLATYYRGSKLYVRCGTPCYM 316
            ....|||.:.|:..:.|.||||||||:.:...      |.:.:|.|:|.....|..|..|:..||
Yeast   167 LQICSALNYCHEHGIYHCDIKPENLLLDTEDN------VFLCDFGLSTTSTYIKPNVCIGSSYYM 225

  Fly   317 APEMIAMSGY----------------DYQVDSWSLGVTLFYMLCGKMPFASACKNSKEIYAAIMS 365
            .||.|:..|.                ....|.||||:.|..:.|.:.|:..|.|.....|.....
Yeast   226 PPERISFDGRVSSSKSGGHKLGKVCPSCNGDLWSLGIILINLTCIRNPWLKADKTEDNTYYYFTK 290

  Fly   366 GGPTYPKDMESV--MSPEATQLIDGLLVSDPSYRVPIAELDK 405
            .    |..::.:  :|.:...|:..:|..:|..|:.:.||.|
Yeast   291 D----PNILKQILPLSDDFYSLLSKILQVNPKNRMSLQELMK 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	56/237 (24%)
		PKc_like	164..403	CDD:304357	53/233 (23%)
VHS1	NP_010533.1	STKc_Pat1_like	11..330	CDD:270895	56/237 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930