Protein Alignment CG10177 and CAMK4

DIOPT Version :10

• Sequence 1: NP_651150.1
• Gene: CG10177 / 42772
• FlyBaseID: FBgn0039083
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001735.1
• Gene: CAMK4 / 814
• HGNCID: 1464
• Length: 473
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 77/270 - (28%)
• Similarity: 132/270 - (48%)
• Gaps: 17/270 - (6%)

  Fly   143 EAIQLYIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAEVLRQLQSHPN 207
            :|:..:.|....:.....:::||.:.:..:....:|::.|..   |:.....|..||.:| ||||
Human    40 DALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRL-SHPN 100

  Fly   208 IIELMYTVEDERYMYTVLEHLDCN--MQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRD 270
            ||:|....|....:..|||.:...  ..::::| |..||.||...::..:.|:|::|:..::|||
Human   101 IIKLKEIFETPTEISLVLELVTGGELFDRIVEK-GYYSERDAADAVKQILEAVAYLHENGIVHRD 164

  Fly   271 IKPENLLVCSSSGKWNFKMVKVANFDLATYYRGSKLY-VRCGTPCYMAPEMIAMSGYDYQVDSWS 334
            :||||||..:.:..   ..:|:|:|.|:.......|. ..||||.|.|||::....|..:||.||
Human   165 LKPENLLYATPAPD---APLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWS 226

  Fly   335 LGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVP 399
            :|:..:.:|||..||... :..:.::..|::....:.......:|..|..|:..|:|.||..|
Human   227 VGIITYILLCGFEPFYDE-RGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKR-- 288

  Fly   400 IAELDKFQFL 409
               |..||.|
Human   289 ---LTTFQAL 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	74/247 (30%)
CAMK4	NP_001735.1	STKc_CaMKIV	42..335	CDD:270987	76/268 (28%)
		Autoinhibitory domain	305..321
		PP2A-binding	306..323
		Calmodulin-binding. /evidence=ECO:0000255	322..341
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..473