DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and CAMKV

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_076951.2	Gene:	CAMKV / 79012	HGNCID:	28788	Length:	501	Species:	Homo sapiens

Alignment Length:	297	Identity:	78/297 - (26%)
Similarity:	140/297 - (47%)	Gaps:	34/297 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 TLESMKSHDLP-EAIQLY-----IETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQTQSNDRG 190
            ||...|:::.| |....|     |:|.|..|      |:|.:.:......|.|...|:.....|.
Human     7 TLGDKKNYNQPSEVTDRYDLGQVIKTEEFCE------IFRAKDKTTGKLHTCKKFQKRDGRKVRK 65

  Fly   191 DTYMEAEVLRQLQSHPNIIEL--MYTVEDERYMYTVL----EHLDCNMQKVIQKRGILSEADARS 249
            ....|..:|:.:: ||||::|  ::....|.:::..|    |..|.     |..:|..||.|..:
Human    66 AAKNEIGILKMVK-HPNILQLVDVFVTRKEYFIFLELATGREVFDW-----ILDQGYYSERDTSN 124

  Fly   250 VMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMVKVANFDLATYYRGSKLYVRCGTPC 314
            |:|..:.|:|::|.|:::||::|.|||:..:...  |.|:| :::|.||....| .:...||||.
Human   125 VVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLK--NSKIV-ISDFHLAKLENG-LIKEPCGTPE 185

  Fly   315 YMAPEMIAMSGYDYQVDSWSLGVTLFYMLCGKMPFASACK------NSKEIYAAIMSGGPTYPKD 373
            |:|||::....|...||.|::||.::.:|.|..||....:      :.|.::..|::|...:...
Human   186 YLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSP 250

  Fly   374 MESVMSPEATQLIDGLLVSDPSYRVPIAELDKFQFLA 410
            ....:|..|..|:..|:..:...|:...|....::::
Human   251 YWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWIS 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	67/256 (26%)
		PKc_like	164..403	CDD:304357	66/250 (26%)
CAMKV	NP_076951.2	STKc_CaMK_like	22..286	CDD:270990	73/279 (26%)
		S_TKc	24..286	CDD:214567	73/277 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..501
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900