DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10177 and STK33

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001275990.1	Gene:	STK33 / 65975	HGNCID:	14568	Length:	514	Species:	Homo sapiens

Alignment Length:	374	Identity:	96/374 - (25%)
Similarity:	174/374 - (46%)	Gaps:	73/374 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 VICCCKNE----EIICVKYS---------------------INKDFQRMVD------------SC 120
            |:|.|.::    .::.|:.|                     ||:|.....|            |.
Human    24 VLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQ 88

  Fly   121 KRWGQHHLDSGTLESMKSHDLPEAIQLYIE---TIEPVEHNTRTL-------IYRGQTRANRTKC 175
            ::||:.:...|.:..::           ||   .||.:....|.|       :.....:...||.
Human    89 QQWGRGNFTEGKVPHIR-----------IENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKW 142

  Fly   176 TVKMVNKQTQSNDRGDTYMEAEV--LRQLQSHPNIIELMYTVEDERYMYTVLEHL-DCNMQKVIQ 237
            .:|.|||: ::.......:|.||  |:.:: |.:||.|....|..:.||.|:|.. |..:::::.
Human   143 AIKKVNKE-KAGSSAVKLLEREVNILKSVK-HEHIIHLEQVFETPKKMYLVMELCEDGELKEILD 205

  Fly   238 KRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSS----SGKWNFKMVKVANFDLA 298
            ::|..||.:.|.:::...||:|::|...::|||:|.||::|.||    :.:.|.. :||.:|.||
Human   206 RKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLN-IKVTDFGLA 269

  Fly   299 TYYRG---SKLYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTLFYMLCGKMPFASACKNSKEIY 360
            ...:.   :.|...||||.|||||:|:...|..|.|.||:||.::.:|.|:.||.::  :.::::
Human   270 VKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLAS--SEEKLF 332

  Fly   361 AAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVPIAELDKFQFL 409
            ..|..|...:...:.:.:|..|..::..|:..||::|:...||...|:|
Human   333 ELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711	4/18 (22%)
		S_TKc	164..409	CDD:214567	76/254 (30%)
		PKc_like	164..403	CDD:304357	73/248 (29%)
STK33	NP_001275990.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..91		5/25 (20%)
		STKc_STK33	114..381	CDD:270999	78/271 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..468
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910