DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and spegb

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_021334681.1	Gene:	spegb / 563174	ZFINID:	ZDB-GENE-081104-517	Length:	3608	Species:	Danio rerio

Alignment Length:	336	Identity:	68/336 - (20%)
Similarity:	140/336 - (41%)	Gaps:	41/336 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 TDGSHLTSLSCFRETDIVI------------CCCKNEEIICVKYSINKDFQRMVDSCKRWGQHHL 128
            ::.||.|.:....|..:|:            |..||     :..|::...:..|.:.|::....:
Zfish  1586 SESSHFTFVYDDNECSLVVLNTQADDSGVYTCTAKN-----LAGSVSCKAELTVHTTKQYKDDPM 1645

  Fly   129 DSGTLESMKSHDLPEAIQLYIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQTQSNDRGDTY 193
            :.......|...|.:    |.:..:.:.....:.:.|...:|.:.:...|.::.:.:
Zfish  1646 EDEASILRKMRRLTD----YYDVHKEIGRGAFSYVKRVIQKAGKLEYAAKFISARAK-------- 1698

  Fly   194 MEAEVLRQLQ-----SHPNIIELMYTVEDERYMYTVLEHLDCNMQKVIQKRGILSEADARSVMRC 253
            .:|..||:|.     .|..|:......|.:..:..:.|.....:...:.|:..:.|::.||.:|.
Zfish  1699 RKASALRELNILSHLDHERILYFHDAFEKKNAVIIITELCHEELLDRLTKKSTILESEIRSSVRQ 1763

  Fly   254 TVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMVKVANFDLATYYRGSKL-YVRCGTPCYMA 317
            .:..:.::|||.::|.||||:|:|:...|.    ..:::.:|..|..:...:. |.:.|||.::|
Zfish  1764 LLEGINYLHQLDILHLDIKPDNILMADHSS----DQIRICDFGNAVKFMPDEAQYCKYGTPEFVA 1824

  Fly   318 PEMIAMSGYDYQVDSWSLGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEA 382
            ||::..:......|.|.:||..:..|.|..|||.  :|.:.....|.:....:.:.|.:.:..||
Zfish  1825 PEIVNQTPVSKATDIWPIGVLTYLCLTGVSPFAG--ENDRSSVLNIRNYNVAFEESMFTDLCHEA 1887

  Fly   383 TQLIDGLLVSD 393
            ...:..|||:|
Zfish  1888 KGFVIKLLVAD 1898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711	8/43 (19%)
		S_TKc	164..409	CDD:214567	54/236 (23%)
		PKc_like	164..403	CDD:304357	54/236 (23%)
spegb	XP_021334681.1	I-set	55..137	CDD:254352
		DUF4045	<228..687	CDD:330572
		I-set	781..870	CDD:254352
		I-set	928..1018	CDD:254352
		I-set	1029..1117	CDD:254352
		I-set	1123..1212	CDD:254352
		I-set	1249..1338	CDD:254352
		FN3	1343..1436	CDD:238020
		Ig	<1479..1541	CDD:325142
		I-set	1545..1634	CDD:254352	9/52 (17%)
		PKc_like	1659..1913	CDD:328722	55/258 (21%)
		I-set	2861..2949	CDD:254352
		FN3	2955..3044	CDD:238020
		PKc_like	3296..3552	CDD:328722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900