DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10177 and dapk1

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001093460.1	Gene:	dapk1 / 558314	ZFINID:	ZDB-GENE-060526-177	Length:	1439	Species:	Danio rerio

Alignment Length:	272	Identity:	68/272 - (25%)
Similarity:	133/272 - (48%)	Gaps:	14/272 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 EAIQLYIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNK-QTQSNDRG----DTYMEAEVLRQL 202
            |.::.|.|....:......::.:.:.::...:...|.:.| :::|:.||    |...|..:|:::
Zfish     7 ENVEDYYEIGGELGSGQFAVVKKCRHKSTGVEYAAKFIKKRRSKSSRRGVSKDDIEREVSILKEI 71

  Fly   203 QSHPNIIELMYTVEDERYMYTVLEHL-DCNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQV 266
            | |||:|.|....|::..:..:||.: ...:...:.::..|||.:|...::..:..::::|..::
Zfish    72 Q-HPNVITLHDVFENKHEVILILELVAGGELFDFLAEKESLSEEEATEFLKQILDGVSYLHSKRI 135

  Fly   267 IHRDIKPENLLVCSSSGKWNFKMVKVANFDLATYYR-GSKLYVRCGTPCYMAPEMIAMSGYDYQV 330
            .|.|:||||:::.:.:..  ...:|:.:|.||.... |:......|||.::|||::.......:.
Zfish   136 SHFDLKPENIMLLNRNVP--HPRIKLIDFGLAHKIDFGNDFKNIFGTPEFVAPEVVNYEPLGLEA 198

  Fly   331 DSWSLGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPS 395
            |.||:||..:.:|.|..||..  :|.:|..|.:.:....:.:|..|..|..|...|..||:.||.
Zfish   199 DMWSIGVITYILLSGASPFLG--ENKQETLANVSAVDYEFDEDYFSHTSALAKDFIARLLIKDPK 261

  Fly   396 YRVPIAELDKFQ 407
            .|:.|  ||..|
Zfish   262 KRMTI--LDSLQ 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	65/251 (26%)
		PKc_like	164..403	CDD:304357	62/245 (25%)
dapk1	NP_001093460.1	STKc_DAPK1	7..275	CDD:271096	68/272 (25%)
		S_TKc	13..275	CDD:214567	66/266 (25%)
		Ank_2	<337..409	CDD:289560
		ANK	373..497	CDD:238125
		ANK repeat	378..409	CDD:293786
		Ank_4	379..432	CDD:290365
		ANK repeat	412..442	CDD:293786
		Ank_2	416..508	CDD:289560
		ANK	439..564	CDD:238125
		ANK repeat	444..475	CDD:293786
		ANK repeat	477..508	CDD:293786
		ANK	505..629	CDD:238125
		ANK repeat	510..541	CDD:293786
		Ank_4	513..564	CDD:290365
		ANK repeat	543..574	CDD:293786
		Ank_2	548..635	CDD:289560
		ANK repeat	576..607	CDD:293786
		ANK	604..>671	CDD:238125
		ANK repeat	609..638	CDD:293786
		Ank_4	610..662	CDD:290365
		Death_DAPK1	1310..1399	CDD:260052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900