DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and trioa

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_021323750.1	Gene:	trioa / 557667	ZFINID:	ZDB-GENE-060503-334	Length:	3115	Species:	Danio rerio

Alignment Length:	242	Identity:	74/242 - (30%)
Similarity:	115/242 - (47%)	Gaps:	12/242 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 TLIYRGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAEVLRQLQSHPNIIELMYTVEDERYMYTVL 225
            :::.|...|.::....||.|||:....|:  ...|..||::|| ||:::.|:.|.|.......||
Zfish  2825 SVVKRCDQRGSKRTVAVKFVNKKLMKRDQ--VTHEFSVLQRLQ-HPHLVRLLDTFETSSSYALVL 2886

  Fly   226 EHLD-CNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKM 289
            |..| ..:...|...|.|:|......:|..:.||.::|..:::|.|:|||||:|..|..:   .:
Zfish  2887 EMSDQGRLLDYIVSWGNLTEEKVAFYLRDILEALQYLHNCRIVHLDLKPENLVVEQSPSQ---PL 2948

  Fly   290 VKVANFDLATYYRGSKLYVR--CGTPCYMAPEMIAMSGYDYQVDSWSLGVTLFYMLCGKMPFASA 352
            ||:.:|..|... .|..||.  .|:|.:.|||::.........|.|||||..:.||.|..||..
Zfish  2949 VKLTDFGDAVQL-NSTPYVHPLLGSPEFAAPELVLGDPVSLSSDLWSLGVLTYVMLSGASPFLD- 3011

  Fly   353 CKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVP 399
             ::.:|....|.....::|.|....:|..|...:..||..:||.|.|
Zfish  3012 -ESVEETCLNICRLDFSFPDDYFQGVSQAARDFMCLLLRMEPSKRPP 3057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	74/239 (31%)
		PKc_like	164..403	CDD:304357	74/239 (31%)
trioa	XP_021323750.1	SEC14	61..199	CDD:214706
		SPEC	212..447	CDD:238103
		SPEC	343..589	CDD:238103
		SPEC	590..806	CDD:238103
		SPEC	810..1037	CDD:238103
		SPEC	931..1160	CDD:238103
		SPEC	1166..1266	CDD:197544
		RhoGEF	1316..1488	CDD:238091
		PH1_Kalirin_Trio_like	1495..1627	CDD:270060
		SH3_Kalirin_1	1695..1754	CDD:212786
		SH3-RhoG_link	1752..2000	CDD:318750
		RhoGEF	2007..2180	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2185..2324	CDD:270061
		Atrophin-1	<2364..2523	CDD:331285
		SH3_Kalirin_2	2570..2628	CDD:212787
		I-set	2702..2793	CDD:254352
		PKc_like	2805..3067	CDD:328722	74/242 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900