DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and Camk1

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_598687.1	Gene:	Camk1 / 52163	MGIID:	1098535	Length:	374	Species:	Mus musculus

Alignment Length:	253	Identity:	70/253 - (27%)
Similarity:	120/253 - (47%)	Gaps:	22/253 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 YIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAEVLRQLQSHPNIIELM 212
            :.|.|...:..|:.|:            .:|.:.|:......|....|..||.::: ||||:.|.
Mouse    31 FSEVILAEDKRTQKLV------------AIKCIAKKALEGKEGSMENEIAVLHKIK-HPNIVALD 82

  Fly   213 YTVEDERYMYTVLEHLDCN--MQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPEN 275
            ...|...::|.:::.:...  ..::::| |..:|.||..::...:.|:.::|.|.::|||:||||
Mouse    83 DIYESGGHLYLIMQLVSGGELFDRIVEK-GFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPEN 146

  Fly   276 LLVCSSSGKWNFKMVKVANFDLATYY-RGSKLYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTL 339
            ||..|..   ....:.:::|.|:... .||.|...||||.|:|||::|...|...||.||:||..
Mouse   147 LLYYSLD---EDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIA 208

  Fly   340 FYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYR 397
            :.:|||..||..  :|..:::..|:.....:.......:|..|...|..|:..||..|
Mouse   209 YILLCGYPPFYD--ENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKR 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	66/237 (28%)
		PKc_like	164..403	CDD:304357	66/237 (28%)
Camk1	NP_598687.1	STKc_CaMKI_alpha	16..278	CDD:271069	70/253 (28%)
		Autoinhibitory domain. /evidence=ECO:0000250	276..316
		Calmodulin-binding. /evidence=ECO:0000250	296..317
		Nuclear export signal. /evidence=ECO:0000250	315..321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900