DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and chek2

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_005165087.1	Gene:	chek2 / 336998	ZFINID:	ZDB-GENE-030131-8942	Length:	504	Species:	Danio rerio

Alignment Length:	245	Identity:	79/245 - (32%)
Similarity:	126/245 - (51%)	Gaps:	29/245 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 KCTVKMVNKQ--------TQSNDRGDTYMEAEVLRQLQSHPNII--ELMYTVEDERYMYTVLEHL 228
            |..:|.:||.        |::.:|     |.|:|::: .||.:|  |..|..||..|:  |||::
Zfish   218 KVALKTINKHDFPSIGTATRNAER-----EIEILKKI-DHPCLIKTEDFYQTEDSYYI--VLEYI 274

  Fly   229 D-CNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMVKV 292
            : ..:...|:.:..|.|..|:......:.|:.::|...:||||:||||:|:.|..   :..::|:
Zfish   275 EGGELFGRIKAKKKLEEDIAKLYFYQMLKAVEYLHNNGIIHRDLKPENVLLASHD---DICLIKI 336

  Fly   293 ANFDLATYYRGSKLY-VRCGTPCYMAPEMIAMS---GYDYQVDSWSLGVTLFYMLCGKMPFASAC 353
            .:|:.:.....|.|. ..||||.|:|||:...:   ||...||.|||||.||..|.|..||.:.|
Zfish   337 TDFNQSKILEESSLMKTLCGTPTYVAPEVFTHASTVGYTKAVDYWSLGVLLFICLGGYPPFNTEC 401

  Fly   354 KNSKEIYAAIMSGGPTY-PKDMESVMSPEATQLIDGLLVSDPSYRVPIAE 402
             .:..:...|::|...: |...::| |.||..|:..|||.||..|:.:.|
Zfish   402 -TTMSVREQIINGEYRFIPSQWKNV-SNEAKDLVKKLLVVDPQKRLSVEE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	79/245 (32%)
		PKc_like	164..403	CDD:304357	79/245 (32%)
chek2	XP_005165087.1	FHA	72..174	CDD:238017
		FHA	<73..173	CDD:224630
		STKc_Chk2	186..456	CDD:270986	79/245 (32%)
		S_TKc	193..456	CDD:214567	79/245 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44167
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100