DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and Sik2

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster

Alignment Length:	248	Identity:	75/248 - (30%)
Similarity:	133/248 - (53%)	Gaps:	23/248 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 RANRTKCTVKMVNK-QTQSNDRGDTYMEAEVLRQLQSHPNIIELMYTVEDERYMYTVLEHL-DCN 231
            |..:.:..:|:::| |....:....|.|.|::::|: ||:||:|...:|.:..:|.|.|:. ...
  Fly   161 RITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLK-HPHIIKLYQVMETKNMIYIVSEYASQGE 224

  Fly   232 MQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKM-VKVANF 295
            :...|.|.|.:||:.||......:||:.:.|:..::|||:|.||||:       :..| :|:|:|
  Fly   225 IFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLL-------DLNMNIKIADF 282

  Fly   296 DLATYYR-GSKLYVRCGTPCYMAPEMIAMSGYDY---QVDSWSLGVTLFYMLCGKMPFASACKNS 356
            ..:.::: |..|...||:|.|.|||:  ..|..|   ::|.|||||.|:.::||.:||..:...|
  Fly   283 GFSNHFKPGELLATWCGSPPYAAPEV--FEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQS 345

  Fly   357 KEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVPIAELDKFQFL 409
              :...::||....|    ..||.|...||..:||.:|:.|..|.::.:.:::
  Fly   346 --LRDRVLSGRFRIP----FFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	75/246 (30%)
		PKc_like	164..403	CDD:304357	75/240 (31%)
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	75/246 (30%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	75/246 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930