DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and Mylk3

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_780650.2	Gene:	Mylk3 / 213435	MGIID:	2443063	Length:	795	Species:	Mus musculus

Alignment Length:	332	Identity:	85/332 - (25%)
Similarity:	140/332 - (42%)	Gaps:	53/332 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 QHHLDSGTL--ESMKSH-----------DLPEAIQLYIETIE-------PVEHNT----RTLIYR 165
            |..:|.|.:  |..|.|           .|..|.:..|..::       |.||..    .|||..
Mouse   423 QQGIDPGAVSPEPGKDHAAQGPGRTEAGRLSSAAEAAIVVLDDSAAPPAPFEHRVVSIKDTLISA 487

  Fly   166 GQTRANRT-----------KCTVK--------MVNKQTQSNDRGDTYMEAEVLRQLQSHPNIIEL 211
            |.|.:...           :||.:        .:.|.....||.|...|..::.|| ||.|:|:|
Mouse   488 GYTVSQHEVLGGGRFGQVHRCTERSTGLALAAKIIKVKNVKDREDVKNEVNIMNQL-SHVNLIQL 551

  Fly   212 MYTVEDERYMYTVLEHLDCN--MQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPE 274
            ....|.:.....::|::|..  ..::..::..|:|.|.....|.....:.::||..::|.|:|||
Mouse   552 YDAFESKSSFTLIMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPE 616

  Fly   275 NLLVCSSSGKWNFKMVKVANFDLATYYR-GSKLYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVT 338
            |:|..|.:|    ..:|:.:|.||..|: ..||.|..|||.::|||::......:..|.||:||.
Mouse   617 NILCVSQTG----HQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVI 677

  Fly   339 LFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVPIAEL 403
            .:.:|.|..||..  :...|....|::....:..|....:|.||...:..|||.:.|.|:...:.
Mouse   678 TYMLLSGLSPFLG--ETDAETMNFIVNCSWDFDADTFKGLSEEAKDFVSRLLVKEKSCRMSATQC 740

  Fly   404 DKFQFLA 410
            .|.::|:
Mouse   741 LKHEWLS 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	69/266 (26%)
		PKc_like	164..403	CDD:304357	68/260 (26%)
Mylk3	NP_780650.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..328
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..452		6/28 (21%)
		STKc_MLCK3	486..746	CDD:271094	69/266 (26%)
		S_TKc	494..746	CDD:214567	67/258 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900