DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and dapk-1

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_490840.2	Gene:	dapk-1 / 187322	WormBaseID:	WBGene00003400	Length:	1425	Species:	Caenorhabditis elegans

Alignment Length:	259	Identity:	63/259 - (24%)
Similarity:	109/259 - (42%)	Gaps:	35/259 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LIYRGQTRANRTKCTVKMVNKQTQSND-RGDTYM----EAEVLRQLQSHPNIIELMYTVEDERYM 221
            ::.|.:.|....|...|.:.|:..:.. ||.|..    |..||::::.:.|::||....|....:
Worm    41 VVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDV 105

  Fly   222 YTVLE---------HL---DCNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPE 274
            ..|||         |:   :|           |.|.:|.:.::..:.|:.|:|.|.::|.|||||
Worm   106 IIVLELVSGGELFDHVCAKEC-----------LDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPE 159

  Fly   275 NLLVCSSSGKWNFKMVKVANFDLATYYR-GSKLYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVT 338
            |:::.....    ..:|:.:|.|:.... |:.:....|||.::|||::.........|.|::||.
Worm   160 NVMLKQRGD----SQIKIIDFGLSREIEPGAVVKDMVGTPEFVAPEVVNYEALSPATDMWAVGVV 220

  Fly   339 LFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVPIAE 402
            .:.:|.|..||..  .|..|.::.|......:........|..|...|..|.|.|...|..:.|
Worm   221 TYILLSGGSPFLG--DNRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEE 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	63/257 (25%)
		PKc_like	164..403	CDD:304357	63/257 (25%)
dapk-1	NP_490840.2	PKc_like	25..289	CDD:304357	63/259 (24%)
		S_TKc	28..289	CDD:214567	63/259 (24%)
		Ank_2	356..456	CDD:289560
		ANK	392..512	CDD:238125
		ANK repeat	392..423	CDD:293786
		ANK repeat	425..456	CDD:293786
		ANK	453..578	CDD:238125
		ANK repeat	491..522	CDD:293786
		Ank_2	496..588	CDD:289560
		ANK	521..644	CDD:238125
		ANK repeat	524..555	CDD:293786
		ANK repeat	557..588	CDD:293786
		Ank_2	562..653	CDD:289560
		ANK repeat	590..653	CDD:293786
		P-loop_NTPase	777..>895	CDD:304359
		Death_DAPK1	1304..1386	CDD:260052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900