Protein Alignment CG10177 and chk-2

DIOPT Version :10

• Sequence 1: NP_651150.1
• Gene: CG10177 / 42772
• FlyBaseID: FBgn0039083
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001024271.1
• Gene: chk-2 / 180304
• WormBaseID: WBGene00000499
• Length: 476
• Species: Caenorhabditis elegans
• Alignment Length: 361
• Identity: 91/361 - (25%)
• Similarity: 162/361 - (44%)
• Gaps: 77/361 - (21%)

  Fly   105 VKYSINKDFQRMVDSCKRWGQHHLDSGTLESMK------SHDLPE---------AIQLYIETIEP 154
            :::||::|    .::.:.:...|..:|||.:.:      |.:|..         |:.:::.....
 Worm    97 IQFSIDRD----TETRRIYLHDHSRNGTLVNQEMIGKGLSRELMNGDLISIGIPALIIFVYESAD 157

  Fly   155 VEHNTRTL------------------IYRGQTRANRTKCTVKMVNKQTQSNDR--------GDTY 193
            .:|:...|                  :..|..:::|:...:|.:|  ||.:.|        .|..
 Worm   158 ADHHPEELTKKYHVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLN--TQFSTRCSRAIAKTRDIR 220

  Fly   194 MEAEVLRQLQSHPNIIELMYTVEDERYMYTVLEHLDCN--MQKVIQ---KRGILSEADARSVMRC 253
            .|.||:::| |||||:.:...:...:|.|.|:|::...  ..||:.   .|..|.|:..:.....
 Worm   221 NEVEVMKKL-SHPNIVAIYDWITVAKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQ 284

  Fly   254 TVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMVKVANFDLATYYRGS--KLYVRCGTPCYM 316
            .:.|:.::|.:.:.||||||||:| ||.  |....::|:.:|.:|   :.|  ::..|||||.|.
 Worm   285 LIDAILYLHSVGICHRDIKPENIL-CSD--KAERCILKLTDFGMA---KNSVNRMKTRCGTPSYN 343

  Fly   317 APEMIAMSGYDY--QVDSWSLGVTLFYMLCGKMPFASACKNSKEIYA------AIMSGGPTYPKD 373
            |||::|..|.:|  :||.||||..||....|..||:       |.|.      .:::|...:...
 Worm   344 APEIVANEGVEYTPKVDIWSLGCVLFITFSGYPPFS-------EEYTDMTMDEQVLTGRLIFHAQ 401

  Fly   374 MESVMSPEATQLIDGLLVSDPSYRVPIAELDKFQFL 409
            ...: :.|...:|..:|..:||.|....||...|::
 Worm   402 WRRI-TVETQNMIKWMLTVEPSNRPSAVELMSTQWM 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711	0/2 (0%)
		S_TKc	164..409	CDD:214567	79/267 (30%)
chk-2	NP_001024271.1	FHA_CHK2	46..156	CDD:438718	10/62 (16%)
		STKc_Chk2	162..436	CDD:270986	80/290 (28%)