Protein Alignment CG10177 and DAPK3

DIOPT Version :10

• Sequence 1: NP_651150.1
• Gene: CG10177 / 42772
• FlyBaseID: FBgn0039083
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001339.1
• Gene: DAPK3 / 1613
• HGNCID: 2676
• Length: 454
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 63/267 - (23%)
• Similarity: 126/267 - (47%)
• Gaps: 12/267 - (4%)

  Fly   143 EAIQLYIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQTQSN-----DRGDTYMEAEVLRQL 202
            |.::.:.|..|.:......::.:.:.:....:...|.:.|:..|:     .|.:...|..:||::
Human     7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREI 71

  Fly   203 QSHPNIIELMYTVEDERYMYTVLEHLD-CNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQV 266
            : |||||.|....|::..:..:||.:. ..:...:.::..|:|.:|...::..:..:.::|..::
Human    72 R-HPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRI 135

  Fly   267 IHRDIKPENLLVCSSSGKWNFKMVKVANFDLA-TYYRGSKLYVRCGTPCYMAPEMIAMSGYDYQV 330
            .|.|:||||:::...:..  ...:|:.:|.:| ....|::.....|||.::|||::.......:.
Human   136 AHFDLKPENIMLLDKNVP--NPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEA 198

  Fly   331 DSWSLGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPS 395
            |.||:||..:.:|.|..||....|  :|....|.:....:.::..|..|..|...|..|||.||.
Human   199 DMWSIGVITYILLSGASPFLGETK--QETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPK 261

  Fly   396 YRVPIAE 402
            .|:.||:
Human   262 RRMTIAQ 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	60/246 (24%)
DAPK3	NP_001339.1	STKc_DAPK	7..275	CDD:271007	63/267 (24%)
		Activation segment. /evidence=ECO:0000250|UniProtKB:O96017	161..204		12/42 (29%)
		Leucine-zipper. /evidence=ECO:0000303|PubMed:9488481	427..441