DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10177 and DAPK1

DIOPT Version :9

Sequence 1:NP_651150.1 Gene:CG10177 / 42772 FlyBaseID:FBgn0039083 Length:411 Species:Drosophila melanogaster
Sequence 2:NP_001275658.1 Gene:DAPK1 / 1612 HGNCID:2674 Length:1430 Species:Homo sapiens


Alignment Length:267 Identity:68/267 - (25%)
Similarity:131/267 - (49%) Gaps:12/267 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 EAIQLYIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNK-QTQSNDRG----DTYMEAEVLRQL 202
            |.:..|.:|.|.:......::.:.:.::...:...|.:.| :|:|:.||    |...|..:|:::
Human     7 ENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEI 71

  Fly   203 QSHPNIIELMYTVEDERYMYTVLEHL-DCNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQV 266
            | |||:|.|....|::..:..:||.: ...:...:.::..|:|.:|...::..::.:.::|.||:
Human    72 Q-HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQI 135

  Fly   267 IHRDIKPENLLVCSSSGKWNFKMVKVANFDLATYYR-GSKLYVRCGTPCYMAPEMIAMSGYDYQV 330
            .|.|:||||:::...:..  ...:|:.:|.||.... |::.....|||.::|||::.......:.
Human   136 AHFDLKPENIMLLDRNVP--KPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEA 198

  Fly   331 DSWSLGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPS 395
            |.||:||..:.:|.|..||....|  :|..|.:.:....:..:..|..|..|...|..|||.||.
Human   199 DMWSIGVITYILLSGASPFLGDTK--QETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPK 261

  Fly   396 YRVPIAE 402
            .|:.|.:
Human   262 KRMTIQD 268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10177NP_651150.1 DCX 18..108 CDD:214711
S_TKc 164..409 CDD:214567 64/246 (26%)
PKc_like 164..403 CDD:304357 64/246 (26%)
DAPK1NP_001275658.1 STKc_DAPK1 7..275 CDD:271096 68/267 (25%)
Calmodulin-binding 267..334 0/2 (0%)
Autoinhibitory domain. /evidence=ECO:0000250 292..301
ANK 373..497 CDD:238125
ANK repeat 378..409 CDD:293786
ANK 1 378..407
ANK 2 411..440
ANK repeat 412..442 CDD:293786
ANK 439..564 CDD:238125
ANK repeat 444..475 CDD:293786
ANK 3 444..473
ANK repeat 477..508 CDD:293786
ANK 4 477..506
ANK 505..629 CDD:238125
ANK repeat 510..541 CDD:293786
ANK 5 510..539
Ank_2 <515..768 CDD:330894
ANK repeat 543..574 CDD:293786
ANK 6 543..572
ANK repeat 576..607 CDD:293786
ANK 7 576..605
ANK repeat 609..638 CDD:293786
ANK 8 609..638
ANK 9 875..904
ANK 10 1162..1196
Death_DAPK1 1308..1393 CDD:260052
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.