DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and EFHB

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_653316.3	Gene:	EFHB / 151651	HGNCID:	26330	Length:	833	Species:	Homo sapiens

Alignment Length:	332	Identity:	56/332 - (16%)
Similarity:	112/332 - (33%)	Gaps:	105/332 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 HDLPEAIQLYIET------------IEPVEHNTRTLIY--------RGQTRANRTKCTV----KM 179
            |.|...:....||            :.|.|:....||:        ||:.|.......|    |.
Human   493 HKLGRVLDPIAETMNVPPDCTFGACLRPEEYGVGDLIHNRLPDEYLRGKDRQRALIAAVRHHLKK 557

  Fly   180 VNKQ---------TQSNDRGDTYMEAEVLRQLQSHPNIIELMYTVEDERYMYTVLEHLDCNMQKV 235
            ||.|         ...:.:||..::.:.|::.....|:      ..|::.:..:.::.|.:....
Human   558 VNYQKFDTLLAAFRHYDKKGDGMIDKDELQEACDQANL------SLDDKLLDQLFDYCDVDNDGF 616

  Fly   236 I-----------QKRGILSEADARSVMR-----CTVSALAHMHQLQVIHRDIKPENLLV--CSSS 282
            |           :.:.:|.|.:.|.:::     |.....|::.:.:.... ||||::::  ..|:
Human   617 INYLEFANFLNWKDKMLLKEYEERVIIKGRKPDCVNPTEANVEEPEQTLL-IKPEDIVLKEAGST 680

  Fly   283 GKWNFKMVKVANFDLATYYR-------------GSKLYVRCGTPCYM----APEMIAMS---GYD 327
            .|....:::.:: .::.||:             .|..|..||.|...    ||.:..:|   .|.
Human   681 EKTLRTLLRPSD-KVSNYYKTTSSEINAIVGAIPSTCYPICGVPTIRSDIPAPRIRRISDRTNYG 744

  Fly   328 YQVDSWSLGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLI---DGL 389
            .:..::||                       :|..|.:....:.:|.....|.|....|   .|:
Human   745 EEGSAYSL-----------------------LYPTIFARKGVFERDFFKTRSKEEIAEILCNIGV 786

  Fly   390 LVSDPSY 396
            .:||..:
Human   787 KLSDEEF 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	48/295 (16%)
		PKc_like	164..403	CDD:304357	48/295 (16%)
EFHB	NP_653316.3	EF-hand_7	566..626	CDD:290234	7/65 (11%)
EFHB	NP_653316.3	EFh	566..626	CDD:238008	7/65 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900