DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and PNCK

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001034671.3	Gene:	PNCK / 139728	HGNCID:	13415	Length:	426	Species:	Homo sapiens

Alignment Length:	280	Identity:	80/280 - (28%)
Similarity:	132/280 - (47%)	Gaps:	14/280 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 GQH--HLDSGTLESM---KSHDLPEAIQLYIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQ 183
            |:|  .:.:..|:.|   |.|  .|.|....|..|.:.....:.:...|.|.:.....:|.:.|:
Human    70 GRHPSRIPAIALQDMLLLKKH--TEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKK 132

  Fly   184 TQSNDRGDTYMEAEVLRQLQSHPNIIELMYTVEDERYMYTVLEHL-DCNMQKVIQKRGILSEADA 247
            ...........|..|||:: |||||:.|....|...::|..:|.: ...:...|.:||..:|.||
Human   133 ALRGKEALVENEIAVLRRI-SHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDA 196

  Fly   248 RSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMVKVANFDLATYYRGSKLYVRCGT 312
            ..::...:.|::::|.|.::|||:||||||..:   .:....:.|::|.|:....|:.|...|||
Human   197 SHLVGQVLGAVSYLHSLGIVHRDLKPENLLYAT---PFEDSKIMVSDFGLSKIQAGNMLGTACGT 258

  Fly   313 PCYMAPEMIAMSGYDYQVDSWSLGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESV 377
            |.|:|||::....|...||.|:|||..:.:|||..||..  ::..|:::.|:.....:.......
Human   259 PGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYD--ESDPELFSQILRASYEFDSPFWDD 321

  Fly   378 MSPEATQLIDGLLVSDPSYR 397
            :|..|...|..||..||..|
Human   322 ISESAKDFIRHLLERDPQKR 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	70/235 (30%)
		PKc_like	164..403	CDD:304357	70/235 (30%)
PNCK	NP_001034671.3	STKc_CaMKI_beta	94..370	CDD:271071	73/254 (29%)
PNCK	NP_001034671.3	S_TKc	98..353	CDD:214567	72/250 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900