DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and CAPSL

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_006714507.1	Gene:	CAPSL / 133690	HGNCID:	28375	Length:	225	Species:	Homo sapiens

Alignment Length:	209	Identity:	36/209 - (17%)
Similarity:	69/209 - (33%)	Gaps:	72/209 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 HDLPEAIQL---YIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNK--QTQSNDRGDTYMEAEV 198
            ||...|||.   .....:|:|......:.||       ...:|.:.:  :...:|...|....|.
Human    24 HDREMAIQAKKKLTTATDPIERLRLQCLARG-------SAGIKGLGRVFRIMDDDNNRTLDFKEF 81

  Fly   199 LRQLQSHPNI-----IELMY---------TVEDERYMYTVLEHLDCNMQKVIQKR---------G 240
            ::.|..:..:     :|.::         |::...::.|:...:....::||.:.         |
Human    82 MKGLNDYAVVMEKEEVEELFRRFDKDGNGTIDFNEFLLTLRPPMSRARKEVIMQAFRKLDKTGDG 146

  Fly   241 ILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMV---KVANFD------ 296
            :::..|.|.|...     .|..:.|                :|:|:.:.|   .:.|||
Human   147 VITIEDLREVYNA-----KHHPKYQ----------------NGEWSEEQVFRKFLDNFDSPYDKD 190

  Fly   297 -LAT------YYRG 303
             |.|      ||.|
Human   191 GLVTPEEFMNYYAG 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	29/181 (16%)
		PKc_like	164..403	CDD:304357	29/181 (16%)
CAPSL	XP_006714507.1	EF-hand_7	61..118	CDD:290234	6/56 (11%)
		EFh	63..118	CDD:238008	6/54 (11%)
		EF-hand_7	100..157	CDD:290234	7/56 (13%)
		EFh	101..155	CDD:238008	6/53 (11%)
		EF-hand_7	133..202	CDD:290234	15/89 (17%)
		EFh	133..199	CDD:298682	15/86 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900