DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and Stk33

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_473444.1	Gene:	Stk33 / 117229	MGIID:	2152419	Length:	491	Species:	Mus musculus

Alignment Length:	258	Identity:	84/258 - (32%)
Similarity:	138/258 - (53%)	Gaps:	14/258 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LIYRGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAEV-LRQLQSHPNIIELMYTVEDERYMYTVL 225
            :::....:....|..:|.|||: ::.......:|.|| :.:..:|.:||.|....|..:.||.|:
Mouse   124 MVFEAIDKETGAKWAIKKVNKE-KAGSSAMKLLEREVSILKTVNHQHIIHLEQVFESPQKMYLVM 187

  Fly   226 EHL-DCNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKM 289
            |.. |..::.|:.:||..||.:.|.:::...||:|::|...::|||:|.||::|.||....|.:|
Mouse   188 ELCEDGELKAVMDQRGHFSENETRLIIQSLASAIAYLHNKDIVHRDLKLENIMVKSSFIDDNNEM 252

  Fly   290 ---VKVANFDLATYYRGSK----LYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTLFYMLCGKM 347
               :||.:|.|:....||:    :...||||.|||||:|....|..|.|.||:||.:|.:|||:.
Mouse   253 NLNIKVTDFGLSVQKHGSRSEGMMQTTCGTPIYMAPEVINAHDYSQQCDIWSIGVIMFILLCGEP 317

  Fly   348 PFASACKNSKE-IYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVPIAELDKFQFL 409
            ||.:   ||:| :|..|..|...:...:...:|..|...:..|:..||::|:...||...|:|
Mouse   318 PFLA---NSEEKLYELIKKGELRFENPVWESVSDSAKNTLKQLMKVDPAHRITAKELLDNQWL 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	83/254 (33%)
		PKc_like	164..403	CDD:304357	80/248 (32%)
Stk33	NP_473444.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..89
		PKc_like	109..377	CDD:419665	83/256 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..491
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910