Protein Alignment CG10177 and Chek2

DIOPT Version :10

• Sequence 1: NP_651150.1
• Gene: CG10177 / 42772
• FlyBaseID: FBgn0039083
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_446129.1
• Gene: Chek2 / 114212
• RGDID: 621543
• Length: 545
• Species: Rattus norvegicus
• Alignment Length: 329
• Identity: 93/329 - (28%)
• Similarity: 153/329 - (46%)
• Gaps: 52/329 - (15%)

  Fly    90 TDIVICCCKNEEIICVKYSINKDFQRMVDSCKRWGQHHLDSGTLESMKSHDLPEAIQLYIETIEP 154
            ::|.:..|:|:  :.|.:.:..|.|.:..  |.....::.|.||.|....::..|.:
  Rat   190 SEIALSLCRNK--VFVFFDLTVDDQSVYP--KELRDEYIMSKTLGSGACGEVKMAFE-------- 242

  Fly   155 VEHNTRTLIYRGQTRANRTKCTVKMVNKQ---TQSNDRGDT----YMEAEVLRQLQSHPNIIEL- 211
                          |....|..:|:::|:   ..|:...||    ..|.|:|::| :||.||::
  Rat   243 --------------RKTCKKVAIKIISKRRFALGSSREADTAPSVETEIEILKKL-NHPCIIKIK 292

  Fly   212 -MYTVEDERYMYTVLEHLDCN--MQKVI-QKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIK 272
             ::.|||   .|.|||.::..  ..:|: .||  |.||..:......:.|:.::|:..:||||:|
  Rat   293 DVFDVED---YYIVLELMEGGELFDRVVGNKR--LKEATCKLYFYQMLLAVQYLHENGIIHRDLK 352

  Fly   273 PENLLVCSSSGKWNFKMVKVANFDLATYY-RGSKLYVRCGTPCYMAPEMI---AMSGYDYQVDSW 333
            |||:|:.|.....   ::|:.:|..:... ..|.:...||||.|:|||::   ..:||...||.|
  Rat   353 PENVLLSSQEEDC---LIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLISNGTAGYSRAVDCW 414

  Fly   334 SLGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRV 398
            ||||.||..|.|..|| |..|....:...|.||......::.:.:|.:|..|:..|||.||..|:
  Rat   415 SLGVILFICLSGYPPF-SEHKTQVSLKDQITSGKYNLIPEVWTDVSEKALDLVKKLLVVDPKARL 478

  Fly   399 PIAE 402
            ...|
  Rat   479 TTEE 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711	4/17 (24%)
		S_TKc	164..409	CDD:214567	81/255 (32%)
Chek2	NP_446129.1	FHA_CHK2	96..207	CDD:438718	4/18 (22%)
		STKc_Chk2	216..489	CDD:270986	87/301 (29%)