DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10177 and SPEG

DIOPT Version :9

Sequence 1:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_011508781.1	Gene:	SPEG / 10290	HGNCID:	16901	Length:	3277	Species:	Homo sapiens

Alignment Length:	355	Identity:	83/355 - (23%)
Similarity:	144/355 - (40%)	Gaps:	57/355 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 KRHVLLRSAIAHFRRTDGSHLTSLSCFRETDIVICCCKNEE---IICVKYSINKDFQRMVDSCKR 122
            |..|||         |:.||::.:....|..:|:.....::   ..|...::..:.     |||
Human  1530 KDEVLL---------TESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAGEV-----SCK- 1579

  Fly   123 WGQHHLDSGTLESMKSHDLPEAIQLYIETI-EPVEHNTRTL---------IYRGQ--------TR 169
                       ..:..|....|::  :|.: |..:|..|.|         |.||.        .|
Human  1580 -----------AELAVHSAQTAME--VEGVGEDEDHRGRRLSDFYDIHQEIGRGAFSYLRRIVER 1631

  Fly   170 ANRTKCTVKMVNKQTQSNDRGDTYMEAEVLRQLQSHPNIIELMYTVEDERYMYTVLEHLDCNMQK 234
            ::..:...|.:  .:|:..:.....||.:|.:|| |..::......|..|.:..|.|.....:.:
Human  1632 SSGLEFAAKFI--PSQAKPKASARREARLLARLQ-HDCVLYFHEAFERRRGLVIVTELCTEELLE 1693

  Fly   235 VIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFKMVKVANFDLAT 299
            .|.::..:.|::.|:.||..:..:.::||..|:|.|:|||||||.  .|....:.|::.:|..|.
Human  1694 RIARKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVW--DGAAGEQQVRICDFGNAQ 1756

  Fly   300 YYR-GSKLYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTLFYMLCGKMPFASACKNSKEIYAAI 363
            ... |...|.:.|||.::|||::..|......|.|.:||..|..|.|..||..  :|.:.....|
Human  1757 ELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVG--ENDRTTLMNI 1819

  Fly   364 MSGGPTYPKDMESVMSPEATQLIDGLLVSD 393
            .:....:.:.....:|.||...:..:||.|
Human  1820 RNYNVAFEETTFLSLSREARGFLIKVLVQD 1849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10177	NP_651150.1	DCX	18..108	CDD:214711	10/49 (20%)
		S_TKc	164..409	CDD:214567	62/239 (26%)
		PKc_like	164..403	CDD:304357	62/239 (26%)
SPEG	XP_011508781.1	I-set	43..125	CDD:254352
		Ig	45..125	CDD:299845
		I-set	732..821	CDD:254352
		Ig	755..822	CDD:299845
		SPEG_u2	822..878	CDD:293256
		I-set	879..969	CDD:254352
		IGc2	892..959	CDD:197706
		I-set	983..1068	CDD:254352
		Ig	995..1065	CDD:143165
		I-set	1074..1163	CDD:254352
		Ig	1091..1163	CDD:299845
		I-set	1198..1287	CDD:254352
		Ig	1215..1287	CDD:299845
		I-set	1400..1490	CDD:254352
		I-set	1495..1584	CDD:254352	13/79 (16%)
		Ig	1512..1581	CDD:143165	13/76 (17%)
		STKc_SPEG_rpt1	1608..1864	CDD:271010	63/249 (25%)
		S_TKc	1611..1864	CDD:214567	63/246 (26%)
		I-set	2594..2684	CDD:254352
		Ig	2615..2684	CDD:299845
		STKc_SPEG_rpt2	2972..3228	CDD:271013
		S_TKc	2976..3228	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900