Protein Alignment Irk2 and Kcnj13

DIOPT Version :10

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_446060.1
• Gene: Kcnj13 / 94341
• RGDID: 621661
• Length: 360
• Species: Rattus norvegicus
• Alignment Length: 346
• Identity: 120/346 - (34%)
• Similarity: 185/346 - (53%)
• Gaps: 28/346 - (8%)

  Fly    84 SRNFRPGS--MRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFIL 146
            |||.:..:  :.:..||.|.|:|...:.....||..| :|:|.:..::|.:|||.:|.|:.||::
  Rat     3 SRNCKVNAPLLSQRYRRMVTKDGHSTLQMDGAQRGLV-YLRDAWGILMDMRWRWMMLVFSASFVV 66

  Fly   147 SWLFFALIWWLIIYTHGDLEEPH--LPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRT 209
            .||.||::|:.:...:||||..|  .|||.     ..||..|..||:.|.||:|||.|||||...
  Rat    67 HWLVFAVLWYAVAEMNGDLEIDHDVPPENH-----TICVKHITSFTAAFSFSLETQLTIGYGTMF 126

  Fly   210 TSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRV 274
            .|.:||.||.::..|.:.|:|..||:.|...||:.|.|.||.::.|:..||:..:||..:|:|:|
  Rat   127 PSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDLAVVAHKDGKPNLIFQV 191

  Fly   275 GDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSD--LFFIWPMVIEHKIDENS 337
            .:.|.|.:  ..||...:..:..:.||:   |.|.::...|...|:  .|||:|:...|.|..:|
  Rat   192 ANTRPSPL--TSVRVSAVLYQERENGEL---YQTSVDFHLDGISSEECPFFIFPLTYYHTITPSS 251

  Fly   338 PLYNLNATDMLQDK----FEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQA 398
            ||..|     ||.:    ||:||.|....|.||:..|.|:||:.:||:..||| ..::.......
  Rat   252 PLATL-----LQHETPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHRF-AALMTRGSKGE 310

  Fly   399 YEIDYARFNETT-QVDTPLCS 418
            |::....|::|. :..||:.|
  Rat   311 YQVKMENFDKTVPEHPTPVVS 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..246	CDD:460023	58/147 (39%)
		IRK_C	253..424	CDD:465439	53/173 (31%)
Kcnj13	NP_446060.1	IRK	21..163	CDD:460023	58/147 (39%)
		Selectivity filter. /evidence=ECO:0000305	119..124		4/4 (100%)
		IRK_C	170..331	CDD:465439	52/171 (30%)