Protein Alignment Irk2 and kcnj10

DIOPT Version :10

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001072312.1
• Gene: kcnj10 / 779765
• XenbaseID: XB-GENE-5777345
• Length: 378
• Species: Xenopus tropicalis
• Alignment Length: 352
• Identity: 140/352 - (39%)
• Similarity: 205/352 - (58%)
• Gaps: 14/352 - (3%)

  Fly    88 RP--GSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLF 150
            ||  ||..| |||.:.|:|..||...|:..:...:|:|::||.:|.|||:.||.|:.:|..:|..
 Frog    18 RPLIGSSLR-RRRVMTKDGRSNVRMDHIADKGFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFV 81

  Fly   151 FALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECP 215
            |.:||:|:...||||.|.:.|.|.     .|||..:...|..||||:|:|.|||||.|..|.|||
 Frog    82 FGVIWYLVALVHGDLLEFNAPANH-----TPCVMQVHTLTGAFLFSLESQTTIGYGFRYISEECP 141

  Fly   216 EAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKS 280
            .||.::..|.:...:...|:.|...||:.|.|:||:|:.||::||:.|.:|.|.||.||.:||||
 Frog   142 YAIVLLITQLVLTTIMEIFITGTFLAKIARPKKRAETIKFSQNAVVSQHEGKLCLMIRVANMRKS 206

  Fly   281 HIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNAT 345
            .:||..|..:|::|..|||||.:......::...|.|....|.|.|:...|.:||:|||.:: |.
 Frog   207 LLIGCQVTGKLLQTHLTKEGENVHLNQINVDFQVDTSSDSPFLILPLTFYHIVDESSPLKDV-AL 270

  Fly   346 DMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETT 410
            ...:..||:||||.||||||..:.|.|:||:..|||||:.|.||:..:.: ..|..|::.|::..
 Frog   271 RSGEGDFELVVILSGTVESTSATCQVRTSYLPEEILWGYEFSPVISVSSN-GKYVADFSLFDQVL 334

  Fly   411 QVDTPLCSAREL----NEIYKIQEGFR 433
            :|..|.|....:    :|..|::|.|:
 Frog   335 KVSPPCCIHETIRFGDSEKLKLEESFK 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..246	CDD:460023	56/145 (39%)
		IRK_C	253..424	CDD:465439	67/174 (39%)
kcnj10	NP_001072312.1	IRK	31..172	CDD:460023	56/145 (39%)
		IRK_C	179..344	CDD:465439	67/166 (40%)