DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and kcnj15

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_005172631.1	Gene:	kcnj15 / 572476	ZFINID:	ZDB-GENE-150928-1	Length:	335	Species:	Danio rerio

Alignment Length:	343	Identity:	120/343 - (34%)
Similarity:	185/343 - (53%)	Gaps:	12/343 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 MRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWW 156
            |....||.|.|:|..||...:::.....||.|::||:||.:||:.:..||.:|:::|..|.::::
Zfish     1 MTNTVRRLVSKDGRSNVKIDNVEGMVKLFLHDLWTTVVDMKWRYKITLFASTFVMTWFVFGVLFY 65

  Fly   157 LIIYTHGDLE-EPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFM 220
            ||...:||.. :|       .|...|||..:...|..:|||:|||.|||||.|..|.|||.||..
Zfish    66 LIGLRNGDFHADP-------SSNHTPCVMNVHTLTGAYLFSLETQTTIGYGFRHVSEECPLAIGA 123

  Fly   221 MCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGA 285
            :..|.:...::..|:.|...||:.|.|:||.|:.||:.||:|:|.|...||.||.:||.|.:|..
Zfish   124 LVLQLVLTGLAEIFVTGAFLAKLARPKKRAGTIKFSRCAVVCRRGGRWCLMVRVANMRSSLLIQC 188

  Fly   286 GVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQD 350
            .:..:|:....|.||:....:.|.::...|.||...|.:.|:...|.:||.|||.:|.|..:.:.
Zfish   189 QLSGKLLAPHVTLEGQKTLVHQTTVDFQMDSSGECPFLLLPLTFYHVLDERSPLADLTAHSLQKR 253

  Fly   351 KFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFN--ETTQVD 413
            .||:::.|..|||||..|.|:|:||:..|||||..|.||:.....  ....|::.|:  :..:..
Zfish   254 DFELLLTLNATVESTAASCQSRTSYLPQEILWGQEFRPVLANTSG--TLSADFSLFHSVQICREQ 316

  Fly   414 TPLCSARELNEIYKIQEG 431
            :......:|.|.|:..:|
Zfish   317 SHTAEKMQLEEEYRGGQG 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	117/335 (35%)
kcnj15	XP_005172631.1	IRK	9..310	CDD:279361	113/309 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930