Protein Alignment Irk2 and kcnj12a

DIOPT Version :9

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: XP_005162964.1
• Gene: kcnj12a / 569146
• ZFINID: ZDB-GENE-131126-14
• Length: 437
• Species: Danio rerio
• Alignment Length: 397
• Identity: 173/397 - (43%)
• Similarity: 243/397 - (61%)
• Gaps: 26/397 - (6%)

  Fly    62 RPTSYYGLSQNGKPFPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYT 126
            |.|:.:|...||          ..|.:..:.|:.|.|.|.|||.|||...::..:..|::.|::|
Zfish    20 RLTTMHGGGMNG----------YGNGKIHTRRKSRNRFVKKNGQCNVQFTNMDEKSQRYMADIFT 74

  Fly   127 TMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTS 191
            |.||.:||:.|:.|.|.|::|||.|.|.:|:|...||||:.|...:|     :.|||..::||.:
Zfish    75 TCVDIRWRYMLIVFTLVFVISWLAFGLAFWVIALLHGDLDNPAGDDN-----FTPCVLQVNGFIA 134

  Fly   192 CFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFS 256
            .||||||||.|||||.|..:.|||.|:|::.||||.|.:...||.|.:.|||.|.|:||||||||
Zfish   135 AFLFSIETQTTIGYGFRCVTEECPLAVFLVVFQSIVGSIIDCFMIGAIMAKMARPKKRAQTLLFS 199

  Fly   257 KHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDL 321
            .:|||..|||.|.||:|||::|||||:.|.||||||:.:.|.|||.:.....::.:|.|.....:
Zfish   200 HNAVIAMRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTTEGEYIPLDQLDINVGFDKGLDRI 264

  Fly   322 FFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRF 386
            |.:.|:.|.|:||..|||:.::..|:....|||||||||.||:|..:.||||||:.:||||||||
Zfish   265 FLVSPITILHQIDHESPLFGISKQDLETADFEIVVILEGMVEATAMTAQARSSYLASEILWGHRF 329

  Fly   387 DPVVLYNKDLQAYEIDYARFNETTQV-DTPLCSARELNEIYKIQEGFRTPAETTFTMRQ----LS 446
            :||:...|:  .|::||:.|::|.:| .||.|||:::.|    .:....|...:|....    ||
Zfish   330 EPVLFEEKN--QYKVDYSHFHKTYEVPSTPRCSAKDMME----NKYLVVPTANSFCYENELAILS 388

  Fly   447 HNHSDQA 453
            |...|.:
Zfish   389 HEEEDDS 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	158/334 (47%)
kcnj12a	XP_005162964.1	IRK_N	2..47	CDD:285640	8/36 (22%)
		IRK	48..371	CDD:279361	158/333 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7793
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2116
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6393
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.980