DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and kcnj1b

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001092204.1	Gene:	kcnj1b / 556608	ZFINID:	ZDB-GENE-070620-9	Length:	375	Species:	Danio rerio

Alignment Length:	333	Identity:	127/333 - (38%)
Similarity:	192/333 - (57%)	Gaps:	22/333 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 RRVRR-RAVFKNGDCNV------VQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLF 150
            |::|| |.|.|:|.||:      .|.|.     .||:|.:||.|:..|.:.:|.||.:|..||..
Zfish    16 RKIRRTRLVTKDGHCNIKFGTTEYQSHF-----AFLKDFWTTFVEIHWCFVILLFAAAFTGSWFV 75

  Fly   151 FALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECP 215
            |.|:|:.:..::|||         .||....|:..|:..|:.||:|:|||.|||||.|..:..||
Zfish    76 FGLLWYSLAKSNGDL---------SESQQTKCIENINSLTTAFLYSLETQTTIGYGGRALTGHCP 131

  Fly   216 EAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKS 280
            ..:.::..||:.|.:.:.||.|::.||::..|:||:|:.||:.|||....|.|.|..||.::||:
Zfish   132 GTVALLIIQSLMGAIINCFMCGLILAKISLPKRRAKTVAFSETAVIRLWKGNLCLQIRVANLRKT 196

  Fly   281 HIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNAT 345
            .:||:.:..:|:||..|.|||.:......::...|....:|||:.|:.|.|.||::||..::.|.
Zfish   197 LLIGSHIYGKLLRTTITPEGETIILDQVNVDFSVDAGKDNLFFVCPLTIYHVIDKSSPFADMAAD 261

  Fly   346 DMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETT 410
            ::....||:||.|:||.|||..|.|.|:||:..||.||:.|.||:...| ...|.||.:.|::|.
Zfish   262 NLQLQDFELVVFLDGTAESTSLSCQVRTSYLPREIKWGYVFLPVISRTK-TGKYRIDLSNFSKTQ 325

  Fly   411 QVDTPLCS 418
            |.|||.|:
Zfish   326 QADTPHCA 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	123/325 (38%)
kcnj1b	NP_001092204.1	IRK	24..342	CDD:307239	123/325 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920