Protein Alignment Irk2 and kcnj1a.2

DIOPT Version :10

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001014334.2
• Gene: kcnj1a.2 / 541499
• ZFINID: ZDB-GENE-050327-22
• Length: 370
• Species: Danio rerio
• Alignment Length: 336
• Identity: 127/336 - (37%)
• Similarity: 203/336 - (60%)
• Gaps: 13/336 - (3%)

  Fly    93 RRVRR-RAVFKNGDCNV-VQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIW 155
            :|:|: |.|.|:|.||: ....|.|.|..::.|.:||:|:.:||:.||.|..||.|||..|.|:|
Zfish    16 QRIRKNRLVTKDGRCNIEFGNVLHRSRFTYVLDFWTTLVETRWRFILLYFVASFTLSWFIFGLLW 80

  Fly   156 WLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFM 220
            :.:..::|||...:.|.:.:     |||.:::..|..:|:|:|:|.|||||....:.:||..:.:
Zfish    81 YWLARSNGDLLWQNPPPDHK-----PCVYSVNDLTYAYLYSLESQATIGYGNVYVTDQCPAGVAL 140

  Fly   221 MCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGA 285
            :..|.:.|::.|.|..|||..|:|..|:||:|:.||:.||||.:.|||.|..||.::||:.:||:
Zfish   141 ITIQMLIGLLISIFWCGIVMTKITLPKKRAKTITFSESAVICPKKGTLCLQIRVANLRKTLMIGS 205

  Fly   286 GVRAQLIRTKST-KEGEVMTQYFTELEIGTDDSGSD-LFFIWPMVIEHKIDENSPLYNLNATDML 348
            .:..:|:||..| .|..::.|...:..:   |:|.| |||:.|:.:.|.||::||.:|:.|..|.
Zfish   206 QIYGKLLRTTVTGGETNILDQVSIDFMV---DAGKDNLFFVCPLTLYHIIDKSSPFFNMAADTMH 267

  Fly   349 QDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVD 413
            |..||:||.|:...|:|..|.|.|:|||..||:||:.|.|::..:|: ..|::|::.|.:...|.
Zfish   268 QQDFELVVFLDSMAETTSSSCQVRTSYIPQEIMWGYDFLPIISRSKE-GRYQVDFSNFAKEVPVP 331

  Fly   414 TPLCSARELNE 424
            |..||....||
Zfish   332 TAHCSRCYHNE 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..246	CDD:460023	53/146 (36%)
		IRK_C	253..424	CDD:465439	65/172 (38%)
kcnj1a.2	NP_001014334.2	IRK	24..166	CDD:460023	53/146 (36%)
		IRK_C	173..342	CDD:465439	65/172 (38%)