Protein Alignment Irk2 and Irk1

DIOPT Version :10

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 461
• Identity: 230/461 - (49%)
• Similarity: 289/461 - (62%)
• Gaps: 43/461 - (9%)

  Fly    14 STTIPTTTQANGGEQA---TQPLKKAIEADPDSLDSVISNPQSYPITIVPNRPTSYYGLSQNGKP 75
            ::|..:...:.|||.:   ||..:|         :|::.   |:...|    ..|...:|::..|
  Fly    78 TSTYASNINSTGGESSGSGTQLSRK---------ESILG---SFHRQI----RRSIKAVSESPGP 126

  Fly    76 FPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAF 140
            ..|.   |...|   |.||||:|.|||:|:|||||.::.:||.|:|||::||:||.|||||||.|
  Fly   127 LTRY---RQTRF---SSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVF 185

  Fly   141 ALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWA-----PCVSAIDGFTSCFLFSIETQ 200
            |.||:.||.||..|||:|.|.|.|||..:| :||.....|     .||:.:....|.||:|:|||
  Fly   186 AASFVFSWAFFGFIWWIIAYAHNDLEYTNL-KNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQ 249

  Fly   201 HTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRD 265
            .|||||.|..:.|||||||.||.|.|.||...|||.||||||::|.|:||||||||::||||.||
  Fly   250 TTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRD 314

  Fly   266 GTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIE 330
            |...||||||||||||||.|.||||:||.|.||||||:..|..||.||.|.....|.||||..|.
  Fly   315 GVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIV 379

  Fly   331 HKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKD 395
            ||||.|||||.|:|:|||:::||:||:|||.:||||.:|||||||:.:|:||||||..||.:.|:
  Fly   380 HKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKE 444

  Fly   396 LQAYEIDYARFNETTQVDTPLCSARELNEIYKIQEGFRTPAETTFTMRQLSH------------N 448
            ...||:||..||.|..||||||||::|:|:..............|..|.||.            :
  Fly   445 TGEYEVDYTLFNNTYDVDTPLCSAKQLDELKSEYSKSAKCVNAPFADRTLSASLFQRIASAASVD 509

  Fly   449 HSDQAS 454
            |.|.||
  Fly   510 HLDPAS 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..246	CDD:460023	84/150 (56%)
		IRK_C	253..424	CDD:465439	109/170 (64%)
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	84/150 (56%)
		IRK_C	302..476	CDD:465439	110/173 (64%)