DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irk2 and KCNJ15

DIOPT Version :10

Sequence 1:NP_001287485.1 Gene:Irk2 / 42770 FlyBaseID:FBgn0039081 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_002234.2 Gene:KCNJ15 / 3772 HGNCID:6261 Length:375 Species:Homo sapiens


Alignment Length:358 Identity:134/358 - (37%)
Similarity:206/358 - (57%) Gaps:20/358 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 RRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIY 160
            |.|.:.|:|..||....:....:.:|||::||::|.:||:.|..||.:|:::|..|.:|::.|.:
Human    26 RPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAF 90

  Fly   161 THGDLE--EPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCF 223
            .|||||  ||       .|...||:..:|..|..||||:|:|.|||||||:.:.|||.|||::..
Human    91 IHGDLEPGEP-------ISNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVA 148

  Fly   224 QSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVR 288
            |.:...:...|:.|...||:.|.|:||:|:.||..|||.:::|.|.|:.:|.:||||.:|...:.
Human   149 QLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLS 213

  Fly   289 AQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFE 353
            .:|::|..|||||.:......::...|.|....|.|.||...|.:||.|||.:|...::.:.:||
Human   214 GKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFE 278

  Fly   354 IVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCS 418
            :||:|..|||||....|:|:|||..||.||..|.|||..:|: ..|..|:::|.:..:  :|.|:
Human   279 LVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKN-GKYVADFSQFEQIRK--SPDCT 340

  Fly   419 -------ARELNEIYKIQEGFRTPAETTFTMRQ 444
                   .::|.|.|: ||..|.....|..::|
Human   341 FYCADSEKQQLEEKYR-QEDQRERELRTLLLQQ 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irk2NP_001287485.1 IRK 100..246 CDD:460023 56/147 (38%)
IRK_C 253..424 CDD:465439 64/177 (36%)
KCNJ15NP_002234.2 IRK 30..171 CDD:460023 56/147 (38%)
Selectivity filter. /evidence=ECO:0000305 127..132 4/4 (100%)
IRK_C 178..349 CDD:465439 63/173 (36%)

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