DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and KCNJ14

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_037480.1	Gene:	KCNJ14 / 3770	HGNCID:	6260	Length:	436	Species:	Homo sapiens

Alignment Length:	359	Identity:	161/359 - (44%)
Similarity:	226/359 - (62%)	Gaps:	22/359 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GLSQNG-KPFPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDW 131
            ||.:|| .|.|.|          ..:.|.|.|.|.|:|.|||...:|..:..|:|.|::||.||.
Human    30 GLCRNGWAPAPVQ----------SPVGRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDV 84

  Fly   132 QWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFS 196
            :|||..|.|:.||:.|||.|.|.:|||...||||..|..|        |||.|.:..|.:.|||:
Human    85 RWRWMCLLFSCSFLASWLLFGLAFWLIASLHGDLAAPPPP--------APCFSHVASFLAAFLFA 141

  Fly   197 IETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVI 261
            :|||.:||||||:.:.|||.|:..:..|.|.|.:..||:.|.|.|||.:.|:|.:||:||::||:
Human   142 LETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVV 206

  Fly   262 CQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWP 326
            ..||..|.||:|||::|:||::.|.|||||::.:.|.|||.:.....::::|.|.....:|.:.|
Human   207 ALRDHRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSP 271

  Fly   327 MVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVL 391
            :.|.|:||..||||.|...::.:..||:||||||.||:|..:||.||||:..|:||||||:| ||
Human   272 ITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEP-VL 335

  Fly   392 YNKDLQAYEIDYARFNETTQV-DTPLCSARELNE 424
            :.:..| ||:||..|:.|.:| .||:|||:||:|
Human   336 FQRGSQ-YEVDYRHFHRTYEVPGTPVCSAKELDE 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	151/326 (46%)
KCNJ14	NP_037480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..43		7/22 (32%)
		IRK	53..378	CDD:307239	151/326 (46%)
		Selectivity filter. /evidence=ECO:0000250	147..152		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3114
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2176
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.080