Protein Alignment Irk2 and KCNJ13

DIOPT Version :10

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_002233.2
• Gene: KCNJ13 / 3769
• HGNCID: 6259
• Length: 360
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 118/331 - (35%)
• Similarity: 179/331 - (54%)
• Gaps: 26/331 - (7%)

  Fly    97 RRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYT 161
            ||.|.|:|. :.:|....:|.:.:|:|.:..::|.:|||.:|.|:.||::.||.||::|:::...
Human    18 RRMVTKDGH-STLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWYVLAEM 81

  Fly   162 HGDLEEPH--LPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQ 224
            :||||..|  .|||.     ..||..|..||:.|.||:|||.|||||....|.:||.||.::..|
Human    82 NGDLELDHDAPPENH-----TICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQ 141

  Fly   225 SIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRA 289
            .:.|:|..||:.|...||:.|.|.||.::.|:..||:...||..:|:|:|.:.|.|.:  ..||.
Human   142 MLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAHMDGKPNLIFQVANTRPSPL--TSVRV 204

  Fly   290 QLIRTKSTKEGEVMTQYFTELEIGTDDSGSD--LFFIWPMVIEHKIDENSPLYNLNATDMLQDK- 351
            ..:..:..:.|::   |.|.::...|...||  .|||:|:...|.|..:|||..|     ||.:
Human   205 SAVLYQERENGKL---YQTSVDFHLDGISSDECPFFIFPLTYYHSITPSSPLATL-----LQHEN 261

  Fly   352 ---FEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETT-QV 412
               ||:||.|....|.||:..|.|:||:.:||:..|.| ..:|.......|:|....|::|. :.
Human   262 PSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCF-ASLLTRGSKGEYQIKMENFDKTVPEF 325

  Fly   413 DTPLCS 418
            .|||.|
Human   326 PTPLVS 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..246	CDD:460023	57/147 (39%)
		IRK_C	253..424	CDD:465439	55/173 (32%)
KCNJ13	NP_002233.2	IRK	21..163	CDD:460023	57/147 (39%)
		Selectivity filter. /evidence=ECO:0000305	119..124		4/4 (100%)
		IRK_C	170..331	CDD:465439	54/171 (32%)