DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irk2 and KCNJ12

DIOPT Version :10

Sequence 1:NP_001287485.1 Gene:Irk2 / 42770 FlyBaseID:FBgn0039081 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_066292.2 Gene:KCNJ12 / 3768 HGNCID:6258 Length:433 Species:Homo sapiens


Alignment Length:407 Identity:181/407 - (44%)
Similarity:254/407 - (62%) Gaps:31/407 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PITIVPNRPTSYYGLSQNGKPFPRQPSCRSRNFRPGSM---RRVRRRAVFKNGDCNVVQKHLQRR 116
            |.:||.:.....:.::.:|          :..|..|.:   ||.|.|.|.|||.||:...::..:
Human     9 PYSIVSSEEDGLHLVTMSG----------ANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEK 63

  Fly   117 RVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAP 181
            ..|:|.||:||.||.:||:.||.|:|:|:.|||.|.:|:|:|...|||||.      .|..|..|
Human    64 SQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEP------AEGRGRTP 122

  Fly   182 CVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRA 246
            ||..:.||.:.||||||||.|||||:|..:.|||.|:||:..|||.|.:..:||.|.:.|||.|.
Human   123 CVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARP 187

  Fly   247 KQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELE 311
            |:||||||||.:||:..|||.|.||:|||::|||||:.|.||||||:.:.|:|||.:.....:::
Human   188 KKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDID 252

  Fly   312 IGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYI 376
            :|.|.....:|.:.|:.|.|:|||.|||:.::..|:..|.|||||||||.||:|..:|||||||:
Human   253 VGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYL 317

  Fly   377 NTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQV-DTPLCSARELNEIYKIQEGFRTPAETTF 440
            ..||||||||:||:...|:  .|:|||:.|::|.:| .||.|||::|     ::..|..|:..:|
Human   318 ANEILWGHRFEPVLFEEKN--QYKIDYSHFHKTYEVPSTPRCSAKDL-----VENKFLLPSANSF 375

  Fly   441 TMRQ----LSHNHSDQA 453
            ....    ||.:..|:|
Human   376 CYENELAFLSRDEEDEA 392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irk2NP_001287485.1 IRK 100..246 CDD:460023 70/145 (48%)
IRK_C 253..424 CDD:465439 88/171 (51%)
KCNJ12NP_066292.2 IRK_N 2..46 CDD:462486 9/46 (20%)
IRK 47..187 CDD:460023 70/145 (48%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:F1NHE9 143..148 4/4 (100%)
IRK_C 194..366 CDD:465439 88/178 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 387..433 2/6 (33%)
PDZ-binding. /evidence=ECO:0000255 431..433
Blue background indicates that the domain is not in the aligned region.

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