DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and KCNJ12

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_066292.2	Gene:	KCNJ12 / 3768	HGNCID:	6258	Length:	433	Species:	Homo sapiens

Alignment Length:	407	Identity:	181/407 - (44%)
Similarity:	254/407 - (62%)	Gaps:	31/407 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PITIVPNRPTSYYGLSQNGKPFPRQPSCRSRNFRPGSM---RRVRRRAVFKNGDCNVVQKHLQRR 116
            |.:||.:.....:.::.:|          :..|..|.:   ||.|.|.|.|||.||:...::..:
Human     9 PYSIVSSEEDGLHLVTMSG----------ANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEK 63

  Fly   117 RVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAP 181
            ..|:|.||:||.||.:||:.||.|:|:|:.|||.|.:|:|:|...|||||.      .|..|..|
Human    64 SQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEP------AEGRGRTP 122

  Fly   182 CVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRA 246
            ||..:.||.:.||||||||.|||||:|..:.|||.|:||:..|||.|.:..:||.|.:.|||.|.
Human   123 CVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARP 187

  Fly   247 KQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELE 311
            |:||||||||.:||:..|||.|.||:|||::|||||:.|.||||||:.:.|:|||.:.....:::
Human   188 KKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDID 252

  Fly   312 IGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYI 376
            :|.|.....:|.:.|:.|.|:|||.|||:.::..|:..|.|||||||||.||:|..:|||||||:
Human   253 VGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYL 317

  Fly   377 NTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQV-DTPLCSARELNEIYKIQEGFRTPAETTF 440
            ..||||||||:||:...|:  .|:|||:.|::|.:| .||.|||::|     ::..|..|:..:|
Human   318 ANEILWGHRFEPVLFEEKN--QYKIDYSHFHKTYEVPSTPRCSAKDL-----VENKFLLPSANSF 375

  Fly   441 TMRQ----LSHNHSDQA 453
            ....    ||.:..|:|
Human   376 CYENELAFLSRDEEDEA 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	165/334 (49%)
KCNJ12	NP_066292.2	IRK_N	3..46	CDD:312087	9/46 (20%)
		IRK	47..374	CDD:307239	166/339 (49%)
		Interaction with phosphatidylinositides. /evidence=ECO:0000250	79..81		0/1 (0%)
		Selectivity filter. /evidence=ECO:0000250	143..148		4/4 (100%)
		Interaction with phosphatidylinositides. /evidence=ECO:0000250	183..190		4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..433		2/6 (33%)
		PDZ-binding. /evidence=ECO:0000255	431..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3114
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7793
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2176
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8489
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.880