DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and KCNJ11

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_000516.3	Gene:	KCNJ11 / 3767	HGNCID:	6257	Length:	390	Species:	Homo sapiens

Alignment Length:	398	Identity:	173/398 - (43%)
Similarity:	246/398 - (61%)	Gaps:	36/398 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 PQSYPITIVPNRPTSYYGLSQNGKPFPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQR 115
            |:.|.:|          .|:::    |.:|..|:        |:.|.|.|.|.|:|||..|:: |
Human     9 PEEYVLT----------RLAED----PAKPRYRA--------RQRRARFVSKKGNCNVAHKNI-R 50

  Fly   116 RRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWA 180
            .:.|||||::||:||.:|..|||.|.:||:.|||.||:.||||.:.||||.       ..|....
Human    51 EQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLA-------PSEGTAE 108

  Fly   181 PCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTR 245
            |||::|..|:|.||||||.|.|||:|.|..:.|||.||.::..|:|.|:|.:|.|.|.:|.|..:
Human   109 PCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQ 173

  Fly   246 AKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTEL 310
            |.:||:||:|||||||..|.|.|..|.||||:|||.||.|.:..|::|..::.||||:..:..::
Human   174 AHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDI 238

  Fly   311 EIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDM--LQDKFEIVVILEGTVESTGQSTQARS 373
            .:.....|:.:|.:.|::|.|.||.|||||:|..:|:  .|| .||:|||||.||:||.:||||:
Human   239 PMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQD-LEIIVILEGVVETTGITTQART 302

  Fly   374 SYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQEGFRTPAET 438
            ||:..|||||.||.|:|.  ::...|.:||::|..|.:|.||||:||:|:|.:.:.|.. |.|..
Human   303 SYLADEILWGQRFVPIVA--EEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLEAL-TLASA 364

  Fly   439 TFTMRQLS 446
            ...:|:.|
Human   365 RGPLRKRS 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	159/335 (47%)
KCNJ11	NP_000516.3	IRK	36..357	CDD:279361	158/331 (48%)
KCNJ11	NP_000516.3	Selectivity filter. /evidence=ECO:0000250	130..135		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930