DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and KCNJ9

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_004974.2	Gene:	KCNJ9 / 3765	HGNCID:	6270	Length:	393	Species:	Homo sapiens

Alignment Length:	342	Identity:	174/342 - (50%)
Similarity:	231/342 - (67%)	Gaps:	13/342 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 FRPGS----MRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILS 147
            |.||.    .||.|:|.|.|:|.|||.|.:: |...|:|.|::||:||.|||.:||.|.|::.|:
Human     8 FSPGQEEPPRRRGRQRYVEKDGRCNVQQGNV-RETYRYLTDLFTTLVDLQWRLSLLFFVLAYALT 71

  Fly   148 WLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSP 212
            ||||..|||||.|..||||  ||    |::.|.|||:.::||.:.|||||||:.|||||.|..:.
Human    72 WLFFGAIWWLIAYGRGDLE--HL----EDTAWTPCVNNLNGFVAAFLFSIETETTIGYGHRVITD 130

  Fly   213 ECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDM 277
            :|||.|.::..|:|.|.|.:|||.|.:|.|:::..:||.||:||.|||:..|||.|.|||||||:
Human   131 QCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDL 195

  Fly   278 RKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNL 342
            |.|||:.|.:||:|||::.|.|||.:..:.|:|.:|.|.....||.:.|:||.|:||..||.:..
Human   196 RSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEA 260

  Fly   343 NATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFN 407
            :...:.:|.|||||||||.||:||.:.||||||:..|:||||||..|:......  ||:|||.|:
Human   261 SRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGF--YEVDYASFH 323

  Fly   408 ETTQVDTPLCSARELNE 424
            ||.:|.||.||||||.|
Human   324 ETFEVPTPSCSARELAE 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	167/325 (51%)
KCNJ9	NP_004974.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		6/14 (43%)
		IRK	25..164	CDD:395797	73/145 (50%)
		Selectivity filter. /evidence=ECO:0000250	120..125		4/4 (100%)
		IRK_C	171..334	CDD:407551	84/164 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..393
		PDZ-binding	390..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147188
Domainoid	1	1.000	196	1.000	Domainoid score	I3114
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2176
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	1	1.000	-	-		FOG0000937
OrthoInspector	1	1.000	-	-		mtm8489
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910