Protein Alignment Irk2 and KCNJ8

DIOPT Version :9

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_004973.1
• Gene: KCNJ8 / 3764
• HGNCID: 6269
• Length: 424
• Species: Homo sapiens
• Alignment Length: 398
• Identity: 167/398 - (41%)
• Similarity: 248/398 - (62%)
• Gaps: 28/398 - (7%)

  Fly    57 TIVPNRPTSYYGLSQNGKPFPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFL 121
            :|:|..    |.|::......|:|..|.        |..:.|.:.|:|.||:..|:: |.:.|||
Human     6 SIIPEE----YVLARIAAENLRKPRIRD--------RLPKARFIAKSGACNLAHKNI-REQGRFL 57

  Fly   122 QDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGW--APCVS 184
            ||::||:||.:||.||:.|.:||:.|||.||::|||:.:.|||:.........|:||.  ..||:
Human    58 QDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVCVT 122

  Fly   185 AIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQR 249
            .:..|||.||||||.|.|||:|.|..:.|||.||.::..|:|.|::.:|.|.|.:|.|..:|.:|
Human   123 NVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRR 187

  Fly   250 AQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGT 314
            |:||:||:||||..|:|.|..||||||:|||.||.|.||.|:::..:|.||||:..:..::.:..
Human   188 AETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQLDIPVDN 252

  Fly   315 DDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTE 379
            ....:::|.:.|::|.|.||:.||||:::|||:.....|::|||||.||:||.:||||:|||..|
Human   253 PIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEE 317

  Fly   380 ILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQEGFRTPAETTFTMR- 443
            |.|||||  |.:..::...|.:||::|..|.:|..|.||||||:|         .|:....|::
Human   318 IQWGHRF--VSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELDE---------KPSILIQTLQK 371

  Fly   444 -QLSHNHS 450
             :|||.:|
Human   372 SELSHQNS 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	152/335 (45%)
KCNJ8	NP_004973.1	IRK	37..184	CDD:395797	66/147 (45%)
		Selectivity filter. /evidence=ECO:0000250	140..145		3/4 (75%)
		IRK_C	191..363	CDD:407551	82/182 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..424		3/5 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930