DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irk2 and KCNJ5

DIOPT Version :10

Sequence 1:NP_001287485.1 Gene:Irk2 / 42770 FlyBaseID:FBgn0039081 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_000881.3 Gene:KCNJ5 / 3762 HGNCID:6266 Length:419 Species:Homo sapiens


Alignment Length:392 Identity:168/392 - (42%)
Similarity:247/392 - (63%) Gaps:26/392 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 DSVISNPQSYPITIVPNRPTSYYGLSQNGKPFPRQ-----PSCRSRNFRPGSMRRVRRRAVFKNG 104
            ||..:..|...|.:.|..|          |..|:|     |....|.......::.|:|.:.|:|
Human     4 DSRNAMNQDMEIGVTPWDP----------KKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSG 58

  Fly   105 DCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPH 169
            .|||...::| ...|:|.|::||:||.:||:.||.|.:.:.::||||..|||||.|..|||:  |
Human    59 KCNVHHGNVQ-ETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLD--H 120

  Fly   170 LPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAF 234
            :.:.:    |.|||..:.||.|.|||||||:.|||||.|..:.:|||.|.::..|:|.|.:.:||
Human   121 VGDQE----WIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAF 181

  Fly   235 MAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKE 299
            |.|.:|.|:::.|:||:||:||.:|||..||..|.|||||||:|.|||:.|.:||:||:::.|||
Human   182 MVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKE 246

  Fly   300 GEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVES 364
            ||.:....|::.:|.|.....||.:.|::|.|:|::.||.:.::...:.|::||:||||||.||:
Human   247 GEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEA 311

  Fly   365 TGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQ 429
            ||.:.||||||::||:||||||.||:...|..  ||:||..|::|.:.:||.|.|:||.|:.:  
Human   312 TGMTCQARSSYMDTEVLWGHRFTPVLTLEKGF--YEVDYNTFHDTYETNTPSCCAKELAEMKR-- 372

  Fly   430 EG 431
            ||
Human   373 EG 374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irk2NP_001287485.1 IRK 100..246 CDD:460023 65/145 (45%)
IRK_C 253..424 CDD:465439 83/170 (49%)
KCNJ5NP_000881.3 IRK 54..193 CDD:460023 65/145 (45%)
Selectivity filter. /evidence=ECO:0000250 149..154 4/4 (100%)
IRK_C 200..371 CDD:465439 84/172 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 390..419
Blue background indicates that the domain is not in the aligned region.

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