DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irk2 and KCNJ4

DIOPT Version :9

Sequence 1:NP_001287485.1 Gene:Irk2 / 42770 FlyBaseID:FBgn0039081 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_004972.1 Gene:KCNJ4 / 3761 HGNCID:6265 Length:445 Species:Homo sapiens


Alignment Length:370 Identity:176/370 - (47%)
Similarity:238/370 - (64%) Gaps:28/370 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 YGLSQNGKP-FPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVD 130
            :|.|:||:. .||              |:.|.|.|.|||.|||...:|..:..|::.|::||.||
Human     2 HGHSRNGQAHVPR--------------RKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVD 52

  Fly   131 WQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLE-EPHLPE---NQEESGWA------PCVSA 185
            .:||:.|:.|:.:|::|||||.|::|.|.:.||||| .|.:|.   .....|.|      ||:..
Human    53 TRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMH 117

  Fly   186 IDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRA 250
            ::||...||||:|||.|||||.|..:.|||.|:..:..|||.|.:..:||.|.:.|||.|.|:||
Human   118 VNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRA 182

  Fly   251 QTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTD 315
            ||||||.||||..|||.|.||:|||::|||||:.|.||||||:...|:|||.:.....:|.:|.|
Human   183 QTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYD 247

  Fly   316 DSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEI 380
            .....:|.:.|::|.|:|||:||||.:...::..:.|||||||||.||:|..:|||||||:.:||
Human   248 IGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEI 312

  Fly   381 LWGHRFDPVVLYNKDLQAYEIDYARFNETTQV-DTPLCSARELNE 424
            ||||||:|||...|  ..|::||:||::|.:| .||.||||||.|
Human   313 LWGHRFEPVVFEEK--SHYKVDYSRFHKTYEVAGTPCCSARELQE 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irk2NP_001287485.1 IRK 100..434 CDD:279361 167/336 (50%)
KCNJ4NP_004972.1 IRK 22..178 CDD:395797 67/155 (43%)
Val/Gly/Ala/Pro stretch 91..111 4/19 (21%)
Selectivity filter. /evidence=ECO:0000250 134..139 4/4 (100%)
IRK_C 185..357 CDD:407551 94/173 (54%)
PDZ-binding. /evidence=ECO:0000255 443..445
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 196 1.000 Domainoid score I3114
eggNOG 1 0.900 - - E1_KOG3827
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 363 1.000 Inparanoid score I2176
Isobase 1 0.950 - 0 Normalized mean entropy S4709
OMA 1 1.010 - - QHG59160
OrthoDB 1 1.010 - - D289862at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8489
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11767
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X128
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.930

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