DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and KCNJ3

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_002230.1	Gene:	KCNJ3 / 3760	HGNCID:	6264	Length:	501	Species:	Homo sapiens

Alignment Length:	356	Identity:	157/356 - (44%)
Similarity:	226/356 - (63%)	Gaps:	11/356 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 RRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWL 157
            ::.|:|.|.|||.|||...:|.....|:|.|::||:||.:|||.|..|.|::.::|||.|.:||:
Human    40 KKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWV 104

  Fly   158 IIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMC 222
            |.||.|||.:.|:      ..:.|||:.:..|.|.|||.|||:.|||||.|..:.:|||.|.:..
Human   105 IAYTRGDLNKAHV------GNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFL 163

  Fly   223 FQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGV 287
            ||||.|.:..||:.|.:|.||::.|:||:||:||:||||..|||.|:||||||::|.||::.|.:
Human   164 FQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQI 228

  Fly   288 RAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKF 352
            |.:|::::.|.|||.:.....||::|.......||.:.|:.|.|.||..||.|:|:...|..::|
Human   229 RCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQF 293

  Fly   353 EIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLC 417
            ||||||||.||:||.:.|||:||...|:||||||.||:...:..  :::||::|:.|.:|.||..
Human   294 EIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGF--FKVDYSQFHATFEVPTPPY 356

  Fly   418 SARELNEIYKIQEGFRTPAETTFTMRQLSHN 448
            |.:|..|:..:......||.|....|   ||
Human   357 SVKEQEEMLLMSSPLIAPAITNSKER---HN 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	149/333 (45%)
KCNJ3	NP_002230.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		157/356 (44%)
		IRK	47..187	CDD:395797	66/145 (46%)
		Selectivity filter. /evidence=ECO:0000250	143..148		4/4 (100%)
		IRK_C	194..364	CDD:407551	78/171 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147184
Domainoid	1	1.000	196	1.000	Domainoid score	I3114
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860