Protein Alignment Irk2 and KCNJ1

DIOPT Version :9

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_000211.1
• Gene: KCNJ1 / 3758
• HGNCID: 6255
• Length: 391
• Species: Homo sapiens
• Alignment Length: 362
• Identity: 149/362 - (41%)
• Similarity: 225/362 - (62%)
• Gaps: 15/362 - (4%)

  Fly    94 RVRRRAVFKNGDCNVVQKHLQ-RRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWL 157
            |.|.|.|.|:|.||:...::: :.|..|..|::||::|.:||:.:..|..:|:.||.||.|:|:.
Human    37 RQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYA 101

  Fly   158 IIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMC 222
            :.|.|.||.|.|...|.     .|||..|:|.||.||||:|||.|||||.|..:.:|..|||::.
Human   102 VAYIHKDLPEFHPSANH-----TPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLI 161

  Fly   223 FQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGV 287
            ||||.||:.::||.|.:.||::|.|:||:|:.|||:|||.:|.|.|.|:.||.::|||.:||:.:
Human   162 FQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHI 226

  Fly   288 RAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKF 352
            ..:|::|..|.|||.:......:....|....:||||.|:.|.|.||.|||.:::.|..:||..|
Human   227 YGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDF 291

  Fly   353 EIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLC 417
            |:||.|:||||||..:.|.|:||:..|:|||:||.|:|...|: ..|.:|:..|::|.:|:||.|
Human   292 ELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKE-GKYRVDFHNFSKTVEVETPHC 355

  Fly   418 SARELNE---IYKIQEGFRTPAETTFTMRQLSHNHSD 451
            :....||   ..:::.|:..|   .|.:.::  |.:|
Human   356 AMCLYNEKDVRARMKRGYDNP---NFILSEV--NETD 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	142/337 (42%)
KCNJ1	NP_000211.1	IRK	43..371	CDD:307239	141/333 (42%)
		Selectivity filter. /evidence=ECO:0000250	141..146		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930