Protein Alignment Irk2 and Kcnj16

DIOPT Version :10

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_445766.2
• Gene: Kcnj16 / 29719
• RGDID: 61824
• Length: 419
• Species: Rattus norvegicus
• Alignment Length: 371
• Identity: 150/371 - (40%)
• Similarity: 213/371 - (57%)
• Gaps: 27/371 - (7%)

  Fly    65 SYYGLSQN----GKPFPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMY 125
            ||||.|..    ...:|..|.    .......||.|||.:.|:|.|||..||:......::.|::
  Rat     2 SYYGSSYRIVNVDSKYPGYPP----EHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIF 62

  Fly   126 TTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGD-LEEPHLPENQEESGWAPCVSAIDGF 189
            ||:||.:||...:.|:||:|||||.|..|:|||...||| |.:|.:         .|||..:..|
  Rat    63 TTLVDTKWRHMFVIFSLSYILSWLIFGSIFWLIALHHGDLLSDPDI---------TPCVDNVHSF 118

  Fly   190 TSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLL 254
            |:.||||:|||.|||||.|..:.||..|:..:..|||...:.:.|:.|...|||..|::||||:.
  Rat   119 TAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIR 183

  Fly   255 FSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGS 319
            ||..|:|..|||.|.||:|:||.|.:|::...|||||:|.....||. ||..|.:|::..|
  Rat   184 FSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGR-MTMAFKDLKLVND---- 243

  Fly   320 DLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGH 384
            .:..:.|:.|.|:||..||||.|:...:.:|.|||:|....|.:|||.|.|:||||:..||||||
  Rat   244 QIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGH 308

  Fly   385 RFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQE 430
            ||..|:...:  :.|:::..:|..:.:|..|.|||::|:  :|.|:
  Rat   309 RFHDVLEVKR--KYYKVNCLQFEGSVEVYAPFCSAKQLD--WKDQQ 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..246	CDD:460023	61/146 (42%)
		IRK_C	253..424	CDD:465439	70/170 (41%)
Kcnj16	NP_445766.2	IRK	37..173	CDD:460023	60/144 (42%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:F1NHE9	131..136		4/4 (100%)
		IRK_C	182..349	CDD:465439	71/175 (41%)