DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and Kcnj5

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_038936903.1	Gene:	Kcnj5 / 29713	RGDID:	61971	Length:	438	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	164/365 - (44%)
Similarity:	241/365 - (66%)	Gaps:	22/365 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SQNGKPFPRQPSCRSRNFRPGSMRRV---------RRRAVFKNGDCNVVQKHLQRRRVRFLQDMY 125
            ||:.|..|:|    :|::.|.:..|.         |:|.:.|.|.|||...::| ...|:|.|::
  Rat    38 SQDHKKIPKQ----ARDYIPIATDRTRLLPEGKKPRQRYMEKTGKCNVHHGNVQ-ETYRYLSDLF 97

  Fly   126 TTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFT 190
            ||:||.:||:.||.|.:.:.::||||..|||||.|..|||:  |:.:.:    |.|||..:.||.
  Rat    98 TTLVDLKWRFNLLVFTMVYTITWLFFGFIWWLIAYVRGDLD--HVGDQE----WIPCVENLSGFV 156

  Fly   191 SCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLF 255
            |.|||||||:.|||||.|..:.:|||.|.::..|:|.|.:.:|||.|.:|.|:::.|:||:||:|
  Rat   157 SAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMF 221

  Fly   256 SKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSD 320
            |.:|||..||..|.|||||||:|.|||:.|.:||:||:::.|||||.:....|::.:|.|.....
  Rat   222 SNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDR 286

  Fly   321 LFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHR 385
            ||.:.|::|.|:|:|.||.:.::...:.|::||:||||||.||:||.:.||||||::||:|||||
  Rat   287 LFLVSPLIISHEINEKSPFWEMSRAQLEQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHR 351

  Fly   386 FDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEI 425
            |.||:...|..  ||:||..|::|.:.:||.|.|:||.|:
  Rat   352 FTPVLTLEKGF--YEVDYNTFHDTYETNTPSCCAKELAEM 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	154/326 (47%)
Kcnj5	XP_038936903.1	IRK	73..212	CDD:395797	65/145 (45%)
Kcnj5	XP_038936903.1	IRK_C	219..390	CDD:407551	85/173 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340839
Domainoid	1	1.000	196	1.000	Domainoid score	I3027
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2118
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	1	1.000	-	-		FOG0000937
OrthoInspector	1	1.000	-	-		mtm12329
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810