Protein Alignment Irk2 and Kcnj8

DIOPT Version :9

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_058795.3
• Gene: Kcnj8 / 25472
• RGDID: 2960
• Length: 424
• Species: Rattus norvegicus
• Alignment Length: 398
• Identity: 168/398 - (42%)
• Similarity: 250/398 - (62%)
• Gaps: 28/398 - (7%)

  Fly    57 TIVPNRPTSYYGLSQNGKPFPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFL 121
            :|:|..    |.|::......|:|..|.        |..:.|.:.|:|.||:..|:: |.:.|||
  Rat     6 SIIPEE----YVLARIAAENLRKPRIRD--------RLPKARFIAKSGACNLAHKNI-REQGRFL 57

  Fly   122 QDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGW--APCVS 184
            ||::||:||.:||.||:.|.:||:.|||.||::|||:.:.|||:.........|:||.  |.||:
  Rat    58 QDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKGITEKSGLESAVCVT 122

  Fly   185 AIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQR 249
            .:..|||.||||||.|.|||:|.|..:.|||.||.::..|:|.|::.:|.|.|.:|.|..:|.:|
  Rat   123 NVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRR 187

  Fly   250 AQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGT 314
            |:||:||:||||..|:|.|..||||||:|||.||.|.||.|:::..:|.||||:..:..::.:..
  Rat   188 AETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQQDIPVDN 252

  Fly   315 DDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTE 379
            ....:::|.:.|::|.|.||:.||||:::|||::....|::|||||.||:||.:||||:|||..|
  Rat   253 PIESNNIFLVAPLIICHVIDKRSPLYDISATDLVNQDLEVIVILEGVVETTGITTQARTSYIAEE 317

  Fly   380 ILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQEGFRTPAETTFTMR- 443
            |.|||||  |.:..::...|.:||::|..|.:|..|.||||||:|         .|:....|::
  Rat   318 IQWGHRF--VSIVTEEEGVYSVDYSKFGNTVRVAAPRCSARELDE---------KPSILIQTLQK 371

  Fly   444 -QLSHNHS 450
             :|||.:|
  Rat   372 SELSHQNS 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	153/335 (46%)
Kcnj8	NP_058795.3	IRK	37..370	CDD:279361	155/344 (45%)
		Selectivity filter. /evidence=ECO:0000250	140..145		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..424		4/6 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930