DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and Kcnj14

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_666075.1	Gene:	Kcnj14 / 211480	MGIID:	2384820	Length:	434	Species:	Mus musculus

Alignment Length:	371	Identity:	161/371 - (43%)
Similarity:	231/371 - (62%)	Gaps:	28/371 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GLSQNGKPFPRQPSCRSRNFRPGSMRRVRRRAVF--KNGDCNVVQKHLQRRRVRFLQDMYTTMVD 130
            ||.:||             :.||.:...|||..|  |:|.|||...:|..:..|:|.|::||.||
Mouse    30 GLCRNG-------------WAPGPVAGSRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVD 81

  Fly   131 WQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLF 195
            .:|||..|.|:.||:.|||.|.|.:|||...||||..|..|        |||.|.:..|.:.|||
Mouse    82 VRWRWMCLLFSCSFLASWLLFGLTFWLIASLHGDLAAPPPP--------APCFSQVASFLAAFLF 138

  Fly   196 SIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAV 260
            ::|||.:||||||:.:.|||.|:..:..|.|.|.:..||:.|.|.|||.:.|:|.:||:||::||
Mouse   139 ALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAV 203

  Fly   261 ICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIW 325
            :..||..|.||:|||::|:||::.|.|||||::.:.|.|||.:.....::::|.|.....:|.:.
Mouse   204 VALRDHRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVS 268

  Fly   326 PMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVV 390
            |:.|.|:||..||||.|...::.:..||:||||||.||:|..:||.||||:..|:||||||:| |
Mouse   269 PITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEP-V 332

  Fly   391 LYNKDLQAYEIDYARFNETTQV-DTPLCSARELNEIYKIQEGFRTP 435
            |:.:..| ||:||..|:.|.:| .||:|||:||:|  :.::...:|
Mouse   333 LFQRGSQ-YEVDYRHFHRTYEVPGTPVCSAKELDE--RAEQASHSP 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	151/336 (45%)
Kcnj14	NP_666075.1	IRK	51..189	CDD:395797	65/145 (45%)
		Selectivity filter. /evidence=ECO:0000250	145..150		3/4 (75%)
		IRK_C	196..369	CDD:407551	82/176 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3119
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2162
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm11121
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.980