Protein Alignment Irk2 and irk-2

DIOPT Version :9

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001368610.1
• Gene: irk-2 / 191695
• WormBaseID: WBGene00002150
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 370
• Identity: 167/370 - (45%)
• Similarity: 237/370 - (64%)
• Gaps: 16/370 - (4%)

  Fly    69 LSQNGK-PFPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQ 132
            |.:|.| ||.:.|       |.|..||:|.|.|.|.|.||:..|::.::|.::..|::||:::.:
 Worm    41 LVKNKKYPFFKTP-------RLGGSRRIRNRLVQKQGLCNISLKNVPKQRRKYFSDIFTTVIEMK 98

  Fly   133 WRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSI 197
            |||.||.|:|||::||.|||.:::||...|||:|:      ...:.|.||:..:....:.||||.
 Worm    99 WRWCLLYFSLSFMISWSFFATVYFLIAKQHGDIEQ------IANATWTPCIVNVHNELNAFLFSF 157

  Fly   198 ETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVIC 262
            .||.|||||.|..:..||..|..||||.::|||:...||||:|:|:.|..:||.||:|||:||||
 Worm   158 TTQTTIGYGFRYPTDACPLTIVTMCFQFMWGVMTQTLMAGIIFSKLARPIKRAATLIFSKNAVIC 222

  Fly   263 QRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPM 327
            .|||.|.|:|||||||||.:..|.||.|:|:...|.|||::..:..::::|.|.....:|.|||:
 Worm   223 LRDGKLCLLFRVGDMRKSSLAEAHVRLQMIKRCVTYEGELLPFHQFDMDVGYDQGLDRVFVIWPI 287

  Fly   328 VIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLY 392
            .|.|:|||.|||:.:.|.|:...||||:.||||.|||.|.:||||:||:.:||||||||:.:|.|
 Worm   288 TICHEIDERSPLWEIGADDLKSAKFEIIAILEGVVESVGSTTQARTSYLPSEILWGHRFEKLVHY 352

  Fly   393 NKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQEGFRTPAE 437
            .|:...|.||:.:|:....|:||.|||.|:..:.  .||....:|
 Worm   353 KKENGQYNIDFGKFHNVYSVNTPTCSAAEIERLR--SEGIFNESE 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	154/333 (46%)
irk-2	NP_001368610.1	IRK	66..206	CDD:395797	61/145 (42%)
		IRK_C	213..387	CDD:407551	87/175 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I1544
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7793
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14333
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.930