DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and Kcnj8

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001317292.1	Gene:	Kcnj8 / 16523	MGIID:	1100508	Length:	424	Species:	Mus musculus

Alignment Length:	398	Identity:	168/398 - (42%)
Similarity:	249/398 - (62%)	Gaps:	28/398 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 TIVPNRPTSYYGLSQNGKPFPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFL 121
            :|:|..    |.|::......|:|..|.        |..:.|.:.|:|.||:..|:: |.:.|||
Mouse     6 SIIPEE----YVLARIAAENLRKPRIRD--------RLPKARFIAKSGACNLAHKNI-REQGRFL 57

  Fly   122 QDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGW--APCVS 184
            ||::||:||.:||.||:.|.:||:.|||.||::|||:.:.|||:.........|:||.  |.||:
Mouse    58 QDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKGTMEKSGLESAVCVT 122

  Fly   185 AIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQR 249
            .:..|||.||||||.|.|||:|.|..:.|||.||.::..|:|.|::.:|.|.|.:|.|..:|.:|
Mouse   123 NVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRR 187

  Fly   250 AQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGT 314
            |:||:||:||||..|:|.|..||||||:|||.||.|.||.|:::..:|.||||:..:..::.:..
Mouse   188 AETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQQDIPVDN 252

  Fly   315 DDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTE 379
            ....:::|.:.|::|.|.||:.||||:::|||:.....|::|||||.||:||.:||||:|||..|
Mouse   253 PIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEE 317

  Fly   380 ILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQEGFRTPAETTFTMR- 443
            |.|||||  |.:..::...|.:||::|..|.:|..|.||||||:|         .|:....|::
Mouse   318 IQWGHRF--VSIVTEEEGVYSVDYSKFGNTVRVAAPRCSARELDE---------KPSILIQTLQK 371

  Fly   444 -QLSHNHS 450
             :|||.:|
Mouse   372 SELSHQNS 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	153/335 (46%)
Kcnj8	NP_001317292.1	IRK	37..184	CDD:366415	67/147 (46%)
		Selectivity filter. /evidence=ECO:0000250	140..145		3/4 (75%)
		IRK_C	191..363	CDD:375232	82/182 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..409		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930