Protein Alignment Irk2 and Kcnj5

DIOPT Version :9

• Sequence 1: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: XP_017168642.1
• Gene: Kcnj5 / 16521
• MGIID: 104755
• Length: 468
• Species: Mus musculus
• Alignment Length: 436
• Identity: 176/436 - (40%)
• Similarity: 262/436 - (60%)
• Gaps: 51/436 - (11%)

  Fly    18 PTTTQANGGEQATQPLKKAIEADPDSLDSVISNPQSYPITIVP---------------------N 61
            |::.||     .|:||::.:...|...:.:.|       |.||                     |
Mouse     7 PSSKQA-----LTEPLRRQLYQTPVRKNLLAS-------TSVPAFDDCKWDGSPAMAGDSRNAMN 59

  Fly    62 RPTSYYGLSQNGKPFPRQ-------PSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVR 119
            :.......||:.|..|:|       .:.|:|....|  ::.|:|.:.|.|.|||...::| ...|
Mouse    60 QDMEIGVTSQDHKKIPKQARDYIPIATDRTRLLTEG--KKPRQRYMEKTGKCNVHHGNVQ-ETYR 121

  Fly   120 FLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVS 184
            :|.|::||:||.:||:.||.|.:.:.::||||..|||||.|..|||:  |:.:.:    |.|||.
Mouse   122 YLSDLFTTLVDLKWRFNLLVFTMVYTITWLFFGFIWWLIAYVRGDLD--HVGDQE----WIPCVE 180

  Fly   185 AIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQR 249
            .:.||.|.|||||||:.|||||.|..:.:|||.|.::..|:|.|.:.:|||.|.:|.|:::.|:|
Mouse   181 NLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKR 245

  Fly   250 AQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGT 314
            |:||:||.:|||..||..|.|||||||:|.|||:.|.:||:||:::.|||||.:....|::.:|.
Mouse   246 AETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGF 310

  Fly   315 DDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTE 379
            |.....||.:.|::|.|:|:|.||.:.::...:.|::||:||||||.||:||.:.||||||::||
Mouse   311 DTGDDRLFLVSPLIISHEINEKSPFWEMSRAQLEQEEFEVVVILEGMVEATGMTCQARSSYMDTE 375

  Fly   380 ILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEI 425
            :||||||.||:...|..  ||:||..|::|.:.:||.|.|:||.|:
Mouse   376 VLWGHRFTPVLTLEKGF--YEVDYNTFHDTYETNTPSCCAKELAEM 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	154/326 (47%)
Kcnj5	XP_017168642.1	IRK	103..242	CDD:366415	65/145 (45%)
		IRK_C	249..420	CDD:375232	85/173 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837128
Domainoid	1	1.000	196	1.000	Domainoid score	I3119
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2162
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	1	1.000	-	-		FOG0000937
OrthoInspector	1	1.000	-	-		mtm8723
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810