DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and Kcnj3

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001342047.1	Gene:	Kcnj3 / 16519	MGIID:	104742	Length:	501	Species:	Mus musculus

Alignment Length:	356	Identity:	156/356 - (43%)
Similarity:	226/356 - (63%)	Gaps:	11/356 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 RRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWL 157
            ::.|:|.|.|||.|||...:|.....|:|.|::||:||.:|||.|..|.|::.::|||.|.:||:
Mouse    40 KKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWV 104

  Fly   158 IIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMC 222
            |.||.|||.:.|:      ..:.|||:.:..|.|.|||.|||:.|||||.|..:.:|||.|.:..
Mouse   105 IAYTRGDLNKAHV------GNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFL 163

  Fly   223 FQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGV 287
            ||||.|.:..||:.|.:|.||::.|:||:||:||:||||..|||.|:||||||::|.||::.|.:
Mouse   164 FQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQI 228

  Fly   288 RAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKF 352
            |.:|::::.|.|||.:.....||::|.......||.:.|:.|.|.||..||.|:|:...|..::|
Mouse   229 RCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQF 293

  Fly   353 EIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLC 417
            |:||||||.||:||.:.|||:||...|:||||||.||:...:..  :::||::|:.|.:|.||..
Mouse   294 EVVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGF--FKVDYSQFHATFEVPTPPY 356

  Fly   418 SARELNEIYKIQEGFRTPAETTFTMRQLSHN 448
            |.:|..|:..:......||.|....|   ||
Mouse   357 SVKEQEEMLLMSSPLIAPAITNSKER---HN 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	148/333 (44%)
Kcnj3	NP_001342047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		156/356 (44%)
		IRK	47..187	CDD:395797	66/145 (46%)
		Selectivity filter. /evidence=ECO:0000250	143..148		4/4 (100%)
		IRK_C	194..364	CDD:407551	77/171 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..501
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8723
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860